Description
Book SynopsisThe aim of this book is to cover the very recent developments in asymmetric organocatalysis, focussing on those published since the beginning of 2008. The last decade has witnessed an explosive growth in the field of asymmetric organocatalysis with an impressive amount of new catalysts, novel methodologies, and applications in numerous reaction types, such as nucleophilic substitutions, addition reactions, as well as cycloadditions, oxidations, reductions, kinetic resolutions, and miscellaneous reactions. This very diverse and intensely developing field is too wide to cover in a single review. The timeliness of the book together with the expected impact is excellent, since nowadays asymmetric organocatalysis is arguably the most intensively developed field in organic chemistry. The book is designed to meet the demands of a postgraduate textbook,containing case studies and Q&A sections, as well as a practical book filled with facts and data useful as a working tool for the practitioner. The book is divided into ten sections, dealing successively with nucleophilic additions to electron-deficient C=C double bonds, nucleophilic additions to C=O double bonds, nucleophilic additions to C=N double bonds, nucleophilic additions to unsaturated nitrogen, nucleophilic substitutions at aliphatic carbon, cycloaddition reactions, oxidations, reductions, kinetic resolutions and desymmetrisations, and miscellaneous reactions.
Trade Review"A strength of the book lies in the extensive use of graphics. Virtually every entry in the book is provided a graphic summary of the best cases for a particular report.""This compilation can be regarded as a snapshot of progress for a field that requires treatment in any modern graduate program in organic chemistry.""...the author has produced a work that is commendable by the measures of the topics selected and their organization." * Journal of the American Chemical Society (JACS),2011, 133, 2330 - 2330, Jeffrey N Johnston *
"...this book was set out to update the audience on the application of asymmetric organocatalysis after several earlier review articles and this certainly meets the task with a plethora of detailed reports on important asymetric organic catalysed processes.""This book will appeal to those researchers engaged in catalysis at phD or post-doctoral level and provides a useful compendium on a wide number of organocatalytic transformations." * Chemistry World, February 2011, Benjamin Buckley *
Table of ContentsIntroduction Nucleophilic additions to electron-deficient C=C double bonds Nucleophilic additions to C=O double bonds Nucleophilic additions to C=N double bonds Nucleophilic additions to unsaturated nitrogen Nucleophilic substitutions at aliphatic carbon Cycloaddition reactions Oxidations Reductions Kinetic resolutions and desymmetrisations Miscellaneous reactions General Conclusion
