Nucleic acid su
Trade Review
"Scientists who like to understand life sciences at a molecular level will use these reviews for at least the next 10 years." (Angewandte Chemie, 2010)
"This is a valuable publication and is a worthwhile addition to the library of any researcher who has an interest in any one (or more) of the subtopics discussed." (JACS, 2010)
Table of Contents
Preface to Series vii Introduction ix
Contributors xi
1. Theoretical Modeling of Radiation-Induced DNA Damage 1
Anil Kumar and Michael D. Sevilla
2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41
William A. Bernhard
3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69
Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. Richard Wagner
4. Reactivity of Nucleic Acid Sugar Radicals 99
Chryssostomos Chatgilialoglu
5. Pyrimidine Nucleobase Radical Reactivity 135
Marc M. Greenberg
6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163
Ryu Tashiro and Hiroshi Sugiyama
7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191
Kiyohiko Kawai and Tetsuro Majima
8. Radical Intermediates During Reductive Electron Transfer Through DNA 211
Reji Varghese and Hans-Achim Wagenknecht
9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239
Leon Sanche
10. Electronic-Affinic Radiosensitizers 295
Peter Wardman
11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325
Vladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov
12. Principles and Applications of Electrochemical Oxidation of Nucleic Acids 357
H. Holden Thorp and Julie M. Sullivan
13. DNA Damage Due to Diradical-Generating Cyclizations 389
Sean M. Kerwin
14. DNA Damage by Phenoxyl Radicals 421
Richard A. Manderville
Index 445
