Description
Book SynopsisThe analysis of drugs and their metabolites in biological media are now expected to routinely achieve 20% accuracy in the ng/mL concentration level. Therefore, the availability and the selection of quality ion-pairs designating the analytes and their isotopically labeled analogs (ILAs) are important considerations in achieving the accuracy of quantitation results. Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused drugs.
Part One of this comprehensive volume illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation. The second section is a systematic compilation of full-scan mass spectra of drugs and their analogs, as parent compounds and as derivatives resulting from various chemical derivatization appro
Trade Review
The information presented in this book is definitely of value to any laboratory engaged in toxicology analysis and the quantification of drugs.
—Maria Reid, Royal Canadian Mounted Police, Canadian Society of Forensic Science, Vol. 43, No. 1, March 2010
The book is of obvious utility to those analysts who work in
drug analysis and to those who are confronted occasionally with
a drug-analysis problem. The strategies outlined in this work are
important to anyone who is conducting trace analysis by
chromatography coupled with mass spectrometry.
—Michael L. Gross, Journal of the American Society for Mass Spectrometry
“Forensic toxicologists would benefit from this book most ... This book shall remain a ready reference tool for me.”
—Anil Aggrawal’s Internet Journal of Forensic Medicine and Toxicology, Vol. 11, No. 1.
The book is of obvious utility to those analysts who work in
drug analysis and to those who are confronted occasionally with
a drug-analysis problem. The strategies outlined in this work are
important to anyone who is conducting trace analysis by
chromatography coupled with mass spectrometry.
—Michael L. Gross, Journal of the American Society for Mass Spectrometry
Table of ContentsIsotopically Labeled Analog as Internal Standard for Drug Quantitation — Methodology. Mass Spectra of Commonly Abused Drugs and Their Isotopically Labelled Analogs in Various Derivatization Forms. Cross-Contributions of Ion Intensity Between Analytes and Their Isotopically Labeled Analogs in Various Derivatization Forms. Index.
