Description
Book SynopsisGuanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemic
Trade ReviewA very useful resource that is an up-to-date record of the state of the field...I am sure that this book will remain as a useful resource for many years. ChemBioChem, 2008, 9, 642-645 (Keith Fox) "Quadruplex Nucleic Acids, edited by Stephen Neidle and Shankar Balasubramanian, contains the most up-to-date information in this rapidly growing field, written by worldclass experts. It is an impressive fusion of knowledge, in a format volume of 297 pages, conveniently split into ten chapters." "In summary, I believe Quadruplex Nucleic Acids provides a very comprehensive and up-to-date overview of chemical, physical and biological properties of G-quadruplex structures. The book not only covers these topics and concepts seamlessly, but also leaps into future directions, discussing potential applications of such structures in nanoscience and supramolecular chemistry. I thoroughly enjoyed reading this well-written and structured book and broadening my own knowledge on the various subjects discussed. This book will not only be an excellent resource for newcomers and experts in the G-quadruplex field, but also should be extremely informative for chemists, physicists and biologists interested in these fascinating G-quadruplex structures, the origins of which preceded the discovery of double helix by 50 years." -- Natalia Gromak, University of Oxford The Biochemist Evolution
Table of ContentsFundamentals of Quadruplex Structures Stephen Neidle and Shankar Balasubramanian; Energetics, Kinetics and Dynamics of Quadruplex Folding; Structural Diversity of G-Quadruplex Scaffolds; The Role of Cations in Determining Quadruplex Structure and Stability; DNA Quadruplex–Ligand Recognition: Structure and Dynamics; Quadruplex Ligand Recognition: Biological Aspects; Quadruplexes and Gene Regulation; Quadruplexes in the Genome; Quadruplexes and the Biology of G-Rich Genomic Regions; The G-Quartet in Supramolecular Chemistry and Nanoscience
