Description

Book Synopsis
Proteins occasionally exhibit the potential to adopt alternate folds under natural or artificial conditions. These conformational changes can lead to the creation of disease-forming amyloid plaques or accumulation of insoluble aggregates in over-expressed recombinant proteins. Because alternate folds challenge the traditional notion of structurally defined proteins and frequently lead to problems in natural and laboratory settings, it is tempting to characterise structurally ambiguous proteins as ill-behaved. Unfortunately, this perspective masks the positive role structural ambiguity can play in protein function and evolution. This book provides leading-edge research on the study of protein misfolding from researchers all over the globe.

Protein Misfolding

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    A Hardback by Cian B O'Doherty, Adam C Byrne

    £999.99

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      Book details

      Publisher Nova Science Publishers Inc
      Published 1 October 2008
      ISBN-13 9781604568813
      978-1604568813
      ISBN-10 160456881X

      Description

      Book Synopsis
      Proteins occasionally exhibit the potential to adopt alternate folds under natural or artificial conditions. These conformational changes can lead to the creation of disease-forming amyloid plaques or accumulation of insoluble aggregates in over-expressed recombinant proteins. Because alternate folds challenge the traditional notion of structurally defined proteins and frequently lead to problems in natural and laboratory settings, it is tempting to characterise structurally ambiguous proteins as ill-behaved. Unfortunately, this perspective masks the positive role structural ambiguity can play in protein function and evolution. This book provides leading-edge research on the study of protein misfolding from researchers all over the globe.

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