Description

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology

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Hardback by Hilmar Weinmann , Craig Crews

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Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly... Read more

    Publisher: Royal Society of Chemistry
    Publication Date: 08/10/2020
    ISBN13: 9781788016865, 978-1788016865
    ISBN10: 1788016866

    Number of Pages: 358

    Non Fiction , Education

    Description

    Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

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