Description
Book SynopsisThe study of pharmacogenetics and pharmacogenomics focuses on how our genes and complex gene systems influence our response to drugs. This textbook discusses the latest information on how human genetics impacts drug response phenotypes, for health care professionals, medical students, pharmacy students, graduate students and researchers in the biosciences.
Table of ContentsIntroduction to population diversity and genetic testing: basic concepts Russ Altman, David Flockhart and David Goldstein; Part I. Critical Concepts: 1. Introduction to population diversity and genetic testing James K. Burmester, Ingrid Glurich, Kimberly Pillsbury and Michael D. Caldwell; 2. Genotyping technologies Sharon Marsh and Cristi R. King; 3. Pharmacokinetics: absorption, distribution, metabolism, excretion Terry Blaschke; 4. Overview: adverse drug reactions Matthew Nelson; 5. PharmGKB, a centralized resource for pharmacogenomic knowledge and discovery Li Gong and Teri E. Klein; 6. DrugBank David S. Wishart; 7. Ethical considerations for pharmacogenomics: privacy and confidentiality Sandra Lee; 8. Informed consent in pharmacogenomic research and treatment Mark Rothstein; 9. Legal trends driving the clinical translation of pharmacogenomics Barbara Evans; Part II. Therapeutic Areas: 10. Pharmacogenetics of oncologic drugs Uchenna Njaju and Eileen Dolan; 11. Pharmacogenetics of cardiovascular drugs Michael Stein and Danny Kurnik; 12. Pharmacogenomics of statin-induced muscle toxicity Ronald M. Krauss, Russell A. Wilke, Melissa Antonik and Elenita Kanin; 13. Pharmacogenomics of the drug-induced long QT syndrome Dan M. Roden, Prince J. Kannankeril, Stefan Kaab and Dawood Darbar; 14. Pharmacogenetics of diabetes drugs O. H. Klungel and Mark C. H. DeGroot; 15. Pharmacogenetics of respiratory drugs Kelan Tantisira and Scott Weiss; 16. Pharmacogenomics for acid-related gastrointestinal drugs Takahisa Furuta; 17. Pharmacogenetics of rheumatoid arthritis drugs Robert M. Plenge, Yvonne C. Lee, Souomya Raychaudhuri and Daniel H. Solomon; 18. Pharmacogenomics of obstetric drugs David Haas and Jamie Renbarger; 19. Pharmacogenomics of psychiatric drugs David Mrazek; 20. Pharmacogenomics of pain and anesthesia drugs Evan Kharasch and Konrad Meissner; 21. Pharmacogenetics of HIV and antiretroviral drugs Amalio Telenti; 22. Pharmacogenomics in pediatrics Jennifer A. Lowry and J. Steven Leeder; 23. Pharmacogenomics in fetal and neonatal medicine Yair Blumenfeld.
