Description
Book SynopsisIn the seven years since the publication of Principles and Practice of Bioanalysis bioanalytical methods have remained the same, but their usage patterns have changed. This second edition of a bestseller provides an updated guide to the techniques used in developing and running ultra-trace analyses for drugs, metabolites, and other substances.
Extensively revised, this volume reflects the dynamic growth in methodologies that has occurred over the past five years. Each chapter has been overhauled or re-written to reflect modern practice. Experts in the field offer a logical path through the problems of small molecule bioanalysis, enabling you to choose the appropriate methods of analysis across a number of fields, including the agrochemical and pharmaceutical industries. They cover a wide range of analytical methods, including mass spectrometry, liquid chromatography, immunoassay, NMR, and gas chromatography.
Presenting the information in an informal and highly ac
Trade Review
"The book consists of 15 chapters written by internationally distinguished experts from biotech and pharmacological companies, mostly located in United Kingdom…. Each chapter contains a bibliography of the most important papers in each field discussed in the book. This book is quite valuable theoretically and methodologically for specialists of various fields of analytical chemistry and biochemistry, molecular biology, and biotechnology. I believe that this book will become an important desk book for researchers working with bioanalysis of various drugs and metabolites."
—G. Ya. Wiederschain, Doctor of Biological Sciences, in Biochemistry, 2008, Vol. 73, No. 12
"… a living guide on the subject, scrutinizing how its topics have changed over the years – mass spectronomy, immunoassay, gas chromatography and more. A scholarly, seminal piece, Principles and Practices of Bioanalysis is highly recommended for community library science collections."
– James A. Cox and Diane C. Donovan in Midwest Book Review, 2008
"I found it instructive and interesting – an adjective that unfortunately can only be applied to textbooks relatively infrequently!"
– E. R. Adlard, in Chromatographia, July 2008, Vol. 68, No. 1/2
Table of ContentsPhysico-chemical Properties of Drugs and Metabolites and their Extraction from Biological Material. Solid Phase Extraction. Basic HPLC Theory and Practice. HPLC Optimisation. HPLC Detectors. Gas Chromotography: What It Is and How We Use It. Thin Layer Chromotography. Capillary Electrophoresis. Immunoassay Techniques. Automation of Sample Preparation. Fundamental Aspects of Mass Spectrometry . Applications of Mass Spectrometry. Quantitative Mass Spectometry. Mass Spectrometric Identification of Metabolites. Nuclear Magnetic Resonance in Drug Metabolism. Strategy in Metabolite Isolation and Identificaiton. Strategy for the Development of Quantitative Analytical Procedures.
