Description
Book SynopsisPhycotoxins are a diverse group of poisonous substances produced by certain seaweed and algae in marine and fresh waters and are important to the scientific community for many reasons, the most obvious being that they pose food safety issues which requires a large investment to regularly monitor the presence of these compounds in foods.
Table of ContentsList of contributors vii
Preface xiii
1 Analysis of marine toxins: gaps on food safety control of marine toxins 1
Paz Otero and Carmen Alfonso
2 Pharmacology of ciguatoxins 23
Carmen Vale, Álvaro Antelo and Víctor Martín
3 Chemistry of pinnatoxins 49
Phillip Mabe and Armen Zakarian
4 Chemistry and analysis of PSP toxins 69
Ana Botana and Verónica Rey López
5 Chemistry of palytoxin and its analogues 85
Patrizia Ciminiello, Carmela Dell’Aversano and Martino Forino
6 Pharmacology of palytoxins and ostreocins 113
M. Carmen Louzao, María Fraga and Natalia Vilarin˜ o
7 Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection 137
Custódia Fonseca, Manuel Aureliano, Feras Abbas and Ambrose Furey
8 Therapeutics of marine toxins 181
Eva Alonso and Juan A. Rubiolo
9 Marine toxins as modulators of apoptosis 203
Amparo Alfonso, Andrea Fernández-Araujo and Mercedes R. Vieytes
10 Cyanobacterial toxins 225
Vitor Vasconcelos, Pedro Leão and Alexandre Campos
11 Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons 239
Antonella Lugliè, Silvia Pulina, Milena Bruno, Bachisio Mario Padedda, Cecilia Teodora Satta, and Nicola Sechi
12 Microalgae as a source of nutraceuticals 255
Sushanta Kumar Saha, Edward McHugh, Patrick Murray and Daniel J. Walsh
13 The marine origin of drugs 293
André Horta, Celso Alves, Susete Pinteus and Rui Pedrosa
14 Pharmacology of cylindrospermopsin 317
Juan A. Rubiolo, Diego Alberto Fernández, Henar López and M. Carmen Louzao
15 Pharmacology of the cyclic imines 343
Natalia Vilarinõ, Sara F. Ferreiro, Andrés Crespo and José Gil
16 Diversity of organic structures of marine microbial origin with drug potential 361
Marcel Jaspars, Rainer Ebel and Hai Deng
17 Polyketides as a source of chemical diversity 381
Tanya Beletskaya, Catherine Collins and Patrick Murray
18 Ichthyotoxins 407
John W. La Claire II and Schonna R. Manning
19 Pathological clues of phycotoxin ingestion 463
Manuel Cifuentes, Andrés Crespo and Roberto Bermúdez
Index 513
