Description
Book SynopsisProviding a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology a leading platform to deliver poorly water soluble drugs, a major hurdle in today s pharmaceutical industry.
Table of ContentsContents
Contributors
Preface
Chapter 1: Introduction to Amorphous Solid DispersionsGeorge Zografi and Ann Newman
Chapter 2: Polymers and SurfactantsPadma Narayan, William W. Porter III, Meinolf Brackhagen, and Christopher Tucker
Chapter 3: Amorphous Solid Dispersion ScreeningAnn Newman
Chapter 4: Solid state Characterization of Amorphous DispersionsFrederick G. Vogt
Chapter 5: Physical Stability and Crystallization InhibitionLynne S. Taylor
Chapter 6: Solubility and Dissolution Considerations for Amorphous Solid DispersionsGrace A. Ilevbare, Wei Xu, Christopher T. John, James Ormes, Jesse Kuiper, Allen C. Templeton, and Annette Bak
Chapter 7: Translational Development of Amorphous DispersionsPatrick Connelly, Brian Patrick Quinn, Steve Johnston, Philip Bransford, Praveen Mudunuri, Andrey Peresypkin, Majed Fawaz, Setu Roday, Anuj Kuldipkumar, Hong-Ren Wang, Phillip Snyder, Jeff Katstra, Tapan Sanghvi, Bill Rowe, and Patricia Hurter
Chapter 8: Preclinical and Clinical StudiesMarcus E. Brewster, Geert Verreck, Jan Bevernage, Joachim Brouwers, Guy Van den Mooter, and Patrick Augustijns
Chapter 9: Spray-Drying and Scale-UpDaniel E. Dobry, Dana M. Settell, and John M. Baumann
Chapter 10: Hot Melt Extrusion of Amorphous Solid DispersionsKieran Crowley and Andreas Gryczke
Chapter 11: Formulation Development of Amorphous DispersionsTapan Sanghvi, Jeff Katstra, Brian Patrick Quinn, Hayden Thomas, and Patricia Hurter
Chapter 12: Scientific and Regulatory Considerations in Product DevelopmentAbhay Gupta, Ziyaur Rahmna, and Manssor A. Khan
Chapter 13: Chapter Patenting Amorphous Solid Dispersions of PharmaceuticalsJeffry A. LindemanChapter 14: Monographs on Polymers and SurfactantsXia Lu, Robert Wenslow, and Ann Newman
Appendix 1
Xia Lu, Robert Wenslow, and Ann Newman
Appendix 2: Marketed Products
Ann Newman
