Description
Book SynopsisParkinson Disease is a comprehensive introduction to the biology and clinical features of Parkinson disease (PD). Topics covered include nosology of PD, PD epidemiology, pathology and pathophysiology of PD, and theories of PD pathogenesis. This book intends to be a useful overview, bridging the gap between general textbooks and specific topical reviews.
Table of ContentsChapter 1: Definition, History, Nosology, and Classification Introduction and Definition Brief History of PD Nosology and Classification Scheme Classification Level 1 Classification Level 2 Ambiguities and Future Directions Conclusion Chapter 2: Epidemiology Introduction Prevalence Incidence Mortality Risk Factors Implications for Understanding Etiopathogenesis and the Future Burden of PD Chapter 3: Pathology Introduction The Aging Brain Gross Pathology, Lewy Pathology, and a-Synucleinopathy Substantia Nigra Pars Compacta Pathology Idiopathic Lewy Body Disease (iLBD) The Braak et al. Staging System Synucleinopathy Outside the Brain Non-Synuclein Pathologies Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model Introduction Basic Basal Ganglia Architecture The "Standard" Model of Basal Ganglia Pathophysiology Complexities of Basal Ganglia Architecture Conclusion Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions Introduction Nigrostriatal Dopamine Signaling Functions Habit Formation and Chunking Cholinergic Projection System Dysfunctions Serotoninergic System Dysfunctions Conclusions and Future Challenges Chapter 6: Genetics of Parkinson Disease Introduction Dominant Forms of PD Recessive Forms of PD GBA PD Genetic Risk Factors Implications of PD Genetic Research Chapter 7: Pathogenesis Neuronal Vulnerability Alpha-Synuclein The Prion-Like Hypothesis Mitochondrial Dysfunction Oxidative Stress Endolysosomal Dysfunction Neuroinflammation Neuroprotection Trials Conclusions Chapter 8: Prodromal Parkinson Disease Introduction REM Sleep Behavior Disorder Observational Studies REM Sleep Behavior Disorder Cohort Studies Genetic Cohort Studies Autonomic Failure Future Directions Chapter 9: Clinical Features I - Initial Evaluation Presentation Features Nature of Diagnosis and Diagnostic Criteria History and Examination Differential Diagnosis Treatment Responsiveness Diagnostic Accuracy Chapter 10: Clinical Features II - Non-Motor Features Introduction Cognitive Impairments Neuropsychiatric Disorders Sleep Disorders Pain Fatigue Autonomic Disorders Visual Disorders Oral Health Conclusion Chapter 11: Clinical Features III - Natural History Introduction Assessing PD Progression PD Progression - Clinically Salient Features Subgroups Natural History Summary Continuing Care End of Life Care Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics Introduction Dopaminergic Neurotransmission L-Dopa Pharmacokinetics L-Dopa Pharmacodynamics Peak Dose Dyskinesias Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions Chapter 13: Pharmacology II - Treating Parkinson Disease Introduction Using L-Dopa When the Honeymoon Is Over L-Dopa Adjuncts Dopamine Agonists Cholinergic Agents Other Symptomatic Therapies Future Directions Chapter 14: Surgery Introduction Deep Brain Stimulation: Rationale and Possible Mechanisms Deep Brain Stimulation: Procedures Deep Brain Stimulation: STN DBS Benefits Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS Deep Brain Stimulation: Adverse Events Lesional Procedures Cell-Based and Gene Therapies Future Directions Coda: Looking Ahead
