Description
Book SynopsisThis book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approaches using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraordinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this hot topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area.
Trade Review"The book is focused on enantioselective organocatalysis in the context of conjugate addition reactions, a vast category of reactions that include some of the most versatile carbon-carbon and carbon-heteroatom bond-forming reactions. The authors are themselves active contributors to the area, including the development of new methodologies"."The overall organisation of this book is excellent, and is based on an appropriate selection of representative protocols that illustrate how different types of chiral organocatalysts can promote conjugate additions and control the sterochemical outcome"."The book is written with clarity and is very well structured"."Each topic is highlighted by seminal contributors from the pioneers on the subject area" * Angew Chem. Claudio Palomo Niucolau *
Table of ContentsIntroduction; Enantioselective conjugate reactions via iminium activation; Enantioselective conjugate reactions via enamine activation; Enantioselective conjugate reactions via hydrogen-bonding activation; Enantioselective conjugate reactions via chiral ammonium ion formation; Organocatalytic enantioselective cascade reactions
