Description
Book SynopsisThis text is the written form of the proceedings of a satellite symposium associated with the 1988-meeting of the Society for Neu roscience. The symposium was held 12 November 1988 in the auditor ium of the Addictions Research Foundation, Toronto, Canada. The ac tual writing took place across the months following the symposium. The symposium was sponsored by the Addictions Research Foundation, Toronto, Canada, the National Institute on Alcohol Abuse and Alcoholism, U. S. A. , and Rensselaer, Troy, NY, U. S. A. Du Pont Pharmaceuticals provided some financial assistance. Contributors also received specific support for their own projects and these are ac knowledged at the end of each chapter. The accomplishment of science involves the efforts of many persons and their organizations. That is surely manifest in the work presented here. Modern science is very expensive and, consequentl
Table of ContentsSection 1 Background.- 1 Obesity, Anorexia Nervosa, and Bulimia: A General Overview.- 2 Alcohol-Abuse and Alcoholism.- 3 The Endogenous Opioidergic Systems.- 4 Opioids’ Modification of Central Reward Processes.- Section 2 Opioids and Ingestion.- 5 Basic Mechanisms of Opioids’ Effects on Eating and Drinking.- 6 Feeding Modified by Central Applications of Opioids.- Section 3 Using Opioid-Antagonists in Treating Bulimia.- 7 Naltrexone and Bulimia: Initial Observations.- 8 Using Drugs to Manage Binge-Eating Among Obese and Normal Weight Patients.- Section 4 Opioids and AA&A, Preclinical Studies.- 9 Opioids Modulate Rats’ Intakes of Alcoholic Beverages.- 10 Opioids Modulate Rats’ Reactivities to Alcohol.- Section 5 Naltrexone and Alcohol-Dependence.- 11 Naltrexone and the Treatment of Alcohol-Dependence: Initial Observations.- Section 6 Individual Differences.- 12 Enkephalinergic Involvement in Voluntary Drinking of Alcohol.- 13 Endorphins in Individuals with High and Low Risk for Development of Alcoholism.- 14 Do Substance-Abuse, Including Alcoholism, and Bulimia Covary?.- Section 7 Prospectives.- 15 Potential Toxicities of High Doses of Naltrexone in Patients with Appetitive Disorders.- 16 Prospects for Developing More Specific Antagonists, I.- 17 Prospects for Developing More Specific Antagonists, II.- 18 Summary.- References.
