Description

Book Synopsis
Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.

Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.

The second section focuses on

Table of Contents
Role of Nucleic Acids in Immunity. Mechanisms and Therapeutic Applications of Immunomodulatory DNA. How Do We Discriminate Self and Non-Self RNA?

Nucleic Acids in Innate Immunity

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    A Hardback by Ken J. Ishii, Shizuo Akira

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      Book details

      Publisher CRC Press Inc
      Published 22 May 2008
      ISBN-13 9781420068252
      978-1420068252
      ISBN-10 1420068253

      Description

      Book Synopsis
      Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.

      Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.

      The second section focuses on

      Table of Contents
      Role of Nucleic Acids in Immunity. Mechanisms and Therapeutic Applications of Immunomodulatory DNA. How Do We Discriminate Self and Non-Self RNA?

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