Description
Book SynopsisPalladium-catalysed cross-coupling reactions constitute a powerful class of chemical methods for the creation of carbon-carbon and carbon-heteroatom bonds used in organic synthesis, famously recognized by the 2010 Nobel Prize awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki ‘for palladium-catalysed cross-couplings in organic synthesis.’ This book provides the reader with the history and basic, concepts of cross-coupling up to the state of the art in modern coupling reactions from both technology and applied perspectives. Edited by Thomas J. Colacot, an expert on cross coupling, the book contains contributions from academic and industrial world leaders in the field, as well as Forewords from Professor Barry M. Trost, Gregory C. Fu and 2010 Nobel Laureate in Chemistry Professor Ei-ichi Negishi. It serves as a reference guide for both undergraduate and graduate students as well as those who are experts in the area. '... this compilation, a “must” for anyone interested in learning and using newer trends in cross-coupling.' Ei-ichi Negishi, 2010 Nobel Laureate in Chemistry 'I am very pleased to see such a book concerning cross coupling reactions published.' Professor Akira Suzuki - 2010 Nobel Laureate in Chemistry '… this book is invaluable to anyone involved in synthesis of organic compounds for any purpose.' Professor Barry Trost, Stanford University
Trade Review"Colacot has brought together a large number of experts in the field and compiled a series of interesting and informative chapters on a variety of cross-coupling areas, with a strong emphasis on the latest developments and a move away from the most conventional topics. ...written in an accessible and clear style, are a must read for those looking for a thorough introduction to the area and some of its trade secrets. ...this book is a welcome addition to an academic’s or industrialist’s bookshelf." -- Igor Larrosa * Chemistry World *
Table of ContentsIntroduction to New Trends in Cross-Coupling; Prominent Ligand Types in Modern Cross-Coupling Reactions; Pd–Phosphine Precatalysts for Modern Cross-Coupling Reactions; Advances in C–C and C–X Coupling Using Palladium–NHeterocyclic Carbene (Pd–NHC) Complexes; Ancillary Ligand Design in the Development of Palladium Catalysts for Challenging Selective Monoarylation Reactions; Transition Metal-Catalyzed Formation of C–O and C–S Bonds; Pd(0)-Catalyzed Carboiodination: Early Developments and Recent Advances; Boron Reagent Activation in Suzuki–Miyaura Coupling; Modern Heck Reactions; Palladium-Catalysed Carbonylative Coupling and C–H Activation; Stereospecific and Stereoselective Suzuki–Miyaura Cross-Coupling Reactions; Direct Arylation via C–H Activation; Cross-Coupling Chemistry in Continuous Flow; Greener Approaches to Cross-Coupling; Recent Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals; Palladium Detection Techniques for Active Pharmaceutical Ingredients Prepared via Cross-Couplings;
