Description
Book SynopsisThere are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas that remain highly neglected. All the major diseases such as malaria, trypanosomatids and TB are covered, with a review of each disease and established compounds, new mechanistic classes and new horizons. Each chapter highlights the key science that has led to breakthroughs, with detailed assessment of the key medicinal chemistry involved, and critical appraisal of new emerging approaches. Later chapters highlight under publicized disease areas where the medical needs are neglected and research is very limited, to raise awareness. The editors, acknowledged experts in the field, have a wealth of experience in successful drug discovery practice and tropical diseases.
Trade Review"fascinating and sobering reading." "an essential purchase for those researching Tropical disease controls." "It Is comprehensive, timely and well referenced" -- John Mann * Chemistry and Industry *
"This is a very timely and valuable review of drug discovery for neglected (tropical) diseases." -- Prof. Ian Gilbert, University of Dundee (UK) * ChemMedChem 2012, 7, 1858 – 1862 *
"The book would be very useful for all those involved in drug discovery for neglected diseases. It will quickly bring scientists moving into neglected disease discovery “up to speed” in the area, and it is also a very good introduction for Ph.D. students." -- Prof. Ian Gilbert, University of Dundee (UK) * ChemMedChem 2012, 7, 1858 – 1862 *
Table of ContentsMalaria; Trypanosomatids; TB; Flavivirus based diseases (Dengue fever, Yellow fever, West Nile virus); Helminth, nematode and schistosoma based diseases; HIV Lower respiratory tract infection; Diarrhea
