Description
Book SynopsisAuthored by leading experts in the enzymology of natural product biosynthesis, this textbook provides a thorough description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500-600,000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, to pharmacognocists and chemical ecologists, to bioengineers and synthetic biologists.
Trade ReviewThis is a highly recommended book for advanced undergraduate and graduate students, as well as for established investigators, interested to learn details on the astonishing metabolic diversity of the biosynthesis of natural products. -- Roberto G. S. Berlinck, Universidade de São Paulo
Table of ContentsMajor Classes of Natural Product Scaffolds and Enzymatic Biosynthetic Machinery; Polyketide Natural Products; Peptide Derived Natural Products; Isoprenoids/Terpenes; Alkaloids; Purine- and Pyrimidine-derived Natural Products; Phenylpropanoid Natural Product Biosynthesis; Indole Terpenes: Alkaloids II; Carbon-based Radicals in C-C Bond Formations in Natural Products. A. Oxygenases B. Oxygen-dependent Halogenases; S-Adenosyl Methionine: One Electron and Two Electron Reaction Manifolds in Biosyntheses; Natural Product Oligosaccharides and Glycosides; Natural Products Isolation and Characterization: Gene Independent Approaches; Natural Products in the Post Genomic Era
