Description
Book SynopsisSince the first publication of this book in 2007, the field of nanoscience and nanomedicine continues to grow substantially. This second edition, Nanotoxicology: Progress toward Nanomedicine, enlists internationally recognized experts to document the continuing development and rationale for the safe design of engineered nanomaterials (ENM). This includes new improved characterization endpoints, screening, and detection methods for in vitro and in vivo toxicity testing. These tools also contribute greatly to nanosafety research applied to nanomedicines.
Topics include
- The impacts of nanotechnology on biomedicine, including functionalization for tissue-specific targeting, the biointeractions of multifunctional nanoparticle-based therapy, and the ability to control specific physicochemical properties of nanoparticles
- The requirements for proper detection, measurement, and assessment both for workplace exposure and in consumer pro
Table of Contents
Impacts of Nanotechnology on Biomedicine. Introduction to Biomedical Nanotechnology. Impact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine. Rational Approach for the Safe Design of Nanomaterials. Characterization of Manufactured Nanomaterials, Dispersion, and Exposure for Toxicological Testing. Exposure. Workplace Inhalation Exposure to Engineered Nanomaterials: Detection, Measurement, and Assessment. Nanotechnology in Consumer Products: Addressing Potential Health and Safety Implications for Consumers. Modeling. Quantitative Nanostructure–Activity Relationships: From Unstructured Data to Predictive Models for Designing Nanomaterials with Controlled Properties. Pharmacokinetics and Biodistribution of Nanomaterials. Methodologies and Techniques. Advanced Methodologies and Techniques for Assessing Nanomaterial Toxicity: From Manufacturing to Nanomedicine Screening. Detection Methods for the In Vivo Biodistribution of Iron Oxide and Silica Nanoparticles: Effects of Size, Surface Chemistry, and Shape. Quantitative Single-Cell Approaches to Assessing Nanotoxicity in Nanomedicine Systems. Imaging Techniques for Nanoparticles in Skin. Hazards. Safety Implications of Nanomaterial Exposure to Skin. Interspecies Comparisons of Pulmonary Responses to Fine and/or Nanoscale Particulates: Relevance for Humans of Particle-Overload Responses in the Rat Model. Current In Vitro Models for Nanomaterial Testing in Pulmonary Systems. Nanoparticles and the Immune System. Carbon Nanotubes and Cardiovascular Disease. Single- and Multiwalled Carbon Nanotubes Toxicity and Potential Applications in Neuroregeneration. Current In Vitro Models for Nanomaterial Testing: The Reproductive System. Current In Vitro Models for Nanomaterial Testing: Genotoxicity Issues. Cell-Based Targeting of Anticancer Nanomaterials to Tumors. Silver Nanoparticles in Biomedical Applications. Cytotoxicity of Conjugated and Unconjugated Semiconductor and Metal Nanoparticles. Risk Assessment. Issues Related to Risk Assessment of Nanomaterials.Risk Assessment of Engineered Nanomaterials: State of the Art and Roadmap for Future Research. Index.
