Description
Book SynopsismRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION
Edited by Joe B. Harford and David R. Morris
Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted.
mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex life of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions.
Topics covered include:
* RNA structure
* Mam
Table of ContentsPartial table of contents:
RNA Structure (E. Puglisi & J. Puglisi).
Transcription and Transcriptional Control: An Overview (I. Olave,et al.).
Constitutive and Alternative mRNA Splicing (S. Bernstein & D.Hodges).
mRNA Polyadenylation: Functional Implications (E. Baker).
RNA Export from the Nucleus (L. Maquat).
The Intracellular mRNA Sorting System: Postal Codes, Zip Codes,Mail Bags and Mail Boxes (O. Steward & R. Singer).
The Fundamentals of Translation Initiation (H. Huang & T.Donahue).
Mechanisms of mRNA Turnover in Eukaryotic Cells (S. Tharun & R.Parker).
Control of mRNA Decay in Plants (A. van Hoof & P. Green).
mRNA Metabolism and Cancer (M. Korth & M. Katze).
Translational Regulation in Animal Virus-Infected Cells (R.Schneider).
RNA Decay by the Interferon-Regulated 2-5A System as a Host DefenseAgainst Viruses (R. Silverman & N. Cirino).
Control of mRNA Stability During Herpes Simplex Virus Infection (G.Read).
Regulation of mRNA Expression in HIV-1 and Other Retroviruses (B.Felber).
Index.
