Description
Book SynopsisPromotes an understanding of steps involved in developing drug leads for industrial partnering and development. This work provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell and molecule based drug screening strategies, as well as mouse models for cancer.
Trade Review"…this little book represents the ever-so-important 'and' that links research and development together in a logical and thoughtful manner...a valuable resource for scientists and clinicians alike…" (
New England Journal of Medicine, January 27, 2005)
"...an excellent publication.… I recommended it for libraries...those involved in cancer research...those who teach pharmacy and medical students about drugs used in the treatment of cancer." (The Annals of Pharmacotherapy, December 2004)
"…provides an up-to-date overview of the different phases of drug discovery and preclinical development of experimental cancer principles.” (Drug Discovery & Development, September 2004)
"…a most informative book, discussing the important evolution in the field of cancer therapeutics…" (American Journal of Therapeutics, July/August 2004)
Table of ContentsPreface.
Contributors.
Chapter 1. Introduction (G. Prendergast).
Chapter 2. Molecular Cancer Therapeutics: Will the Promise Be Fulfilled? (B. Teicher).
Chapter 3. Cancer Genetics and Drug Target Selection (G. Zhang & W. Kaelin).
Chapter 4. RNA Interference in Mammals: Journey to the Center of Human Disease (P. Paddison & G. Hannon).
Chapter 5. Applications and Issues for Tissue Arrays in Target and Drug Discovery (E. Jonasch, K. Do, C. Logothetis, & T. McDonnell).
Chapter 6. Protein Transduction Strategies for Target and Mechanism Validation (S. Ezhevsky & S. Dowdy).
Chapter 7. Drug Screening: Assay Development Issues (S. Carroll, J. Inglese, S. Mao, & D. Olson).
Chapter 8. Gene Microarray Technologies for Cancer Drug Discovery and Development (R. te Poele, P. Clarke, & P. Workman).
Chapter 9. Transgenic Mouse Models of Cancer (T. Bowen & A. Wynshaw-Boris).
Chapter 10. Transgenic versus Xenograft Mouse Models of Cancer: Utility and Issues (M. Liu, W. Bishop, Y. Wang, & P. Kirschmeier).
Chapter 11. Pharmacodynamic Assays in Cancer Drug Discovery: From Preclinical Validation to Clinical Trial Monitoring (R. Lobell, N. Kohl, & L. Sepp-Lorenzino).
Chapter 12. Pharmacokinetic and Toxicology Issues in Cancer Drug Discovery and Development (P. Benfield & B. Car).
Chapter 13. Clinical Development Issues (S. Averbuch, M. Wolf, B. El-Rayes, & P. LoRusso).
Chapter 14. Intellectual Property and Commercialization Issues in Drug Discovery (L. Malseed).
Index.
