Description
Book SynopsisFocusing on the molecular and chemical bases of oxidative stress, which can cause cancer as well as cardiovascular and neurodegenerative diseases, Molecular Basis of Oxidate Stress discusses the role of free radicals in disease, diagnosis, and therapeutics.
Table of ContentsPreface xvii
About the Contributors xix
Contributors xxv
1 Chemistry of Reactive Species 1
Frederick A. Villamena
2 Lipid Peroxidation and Nitration 49
Sean S. Davies and Lilu Guo
3 Protein Posttranslational Modifi cation 71
James L. Hougland, Joseph Darling, and Susan Flynn
4 DNA Oxidation 93
Dessalegn B. Nemera, Amy R. Jones, and Edward J. Merino
5 Downregulation of Antioxidants and Phase 2 Proteins 113
Hong Zhu, Jianmin Wang, Arben Santo, and Yunbo Li
6 Mitochondrial Dysfunction 123
Yeong-Renn Chen
7 NADPH Oxidases: Structure and Function 137
Mark T. Quinn
8 Cell Signaling and Transcription 179
Imran Rehmani, Fange Liu, and Aimin Liu
9 Oxidative Stress and Redox Signaling in Carcinogenesis 203
Rodrigo Franco, Aracely Garcia-Garcia, Thomas B. Kryston, Alexandros G. Georgakilas, Mihalis I. Panayiotidis, and Aglaia Pappa
10 Neurodegeneration from Drugs and Aging-Derived Free Radicals 237
Annmarie Ramkissoon, Aaron M. Shapiro, Margaret M. Loniewska, and Peter G. Wells
11 Cardiac Ischemia and Reperfusion 311
Murugesan Velayutham and Jay L. Zweier
12 Atherosclerosis: Oxidation Hypothesis 329
Chandrakala Aluganti Narasimhulu, Dmitry Litvinov, Xueting Jiang, Zhaohui Yang, and Sampath Parthasarathy
13 Cystic Fibrosis 345
Neal S. Gould and Brian J. Day
14 Biomarkers of Oxidative Stress in Neurodegenerative Diseases 359
Rukhsana Sultana, Giovanna Cenini, and D. Allan Butterfield
15 Synthetic Antioxidants 377
Grégory Durand
References, 398
Index 407
