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Book Synopsis
How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure.

In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer’s disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists.
 
Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result.

Model Systems in Biology History Philosophy and

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    A Hardback by Georg Striedter

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      Publisher: MIT Press Ltd
      Publication Date: Publication Date: 02/08/2022
      ISBN13: 9780262046947, 978-0262046947
      ISBN10: 0262046946
      Also in:
      Biology, life sciences

      Description

      Book Synopsis
      How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure.

      In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer’s disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists.
       
      Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result.

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