Description
Book SynopsisFruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. This book provides accounts of model organism research that have impacted on specific therapeutic areas.
Trade Review"...an invaluable resource for an researcher in the academic or private sector...essential for any graduate level course..." (Drug Discovery Today, Vol 9(7), April 2004)
"...summarised the major organisms of use in this area together with their relative strengths and weaknesses..." (British Society of Cell Biology Newsletter, Summer 2004)
Table of ContentsList of contributors.
Acknowledgments.
1. Introduction to Model Systems in Drug Discovery (Kevin Fitzgerald and Pamela M. Carroll).
2. Growing Yeast for Fun and Profit: Use of Saccharomyces cerevisiae as a Model System in Drug Discovery (Petra Ross-Macdonald).
3. Caenorhabditis elegans Functional Genomics in Drug Discovery: Expanding Paradigms (Titus Kaletta, Lynn Butler and Thierry Bogaert).
4. Drosophila as a Tool for Drug Discovery (Hao Li and Dan Garza).
5. Drosophila – a Model System for Targets and Lead Identification in Cancer and Metabolic Disorders (Corina Schütt, Barbara Froesch and Ernst Hafen).
6. Mechanism of Action in Model Organisms: Interfacing Chemistry, Genetics and Genomics (Pamela M. Carroll, Kevin Fitzgerald and Rachel Kindt).
7. Gene tics and Genomics in the Zebrafish: from Gene to Function and Back (Stefan Schulte-Merker).
8. Lipid Metabolism and Signaling in Zebrafish (Shiu-Ying Ho, Steven A. Farber and Michael Pack).
9. Chemical Mutagenesis in the Mouse: a Powerful Tool in Drug Target Identification and Validation (Andreas Russ, Neil Dear, Geert Mudde, Gabriele Stumm, Johannes Grosse, Andreas Schröder, Reinhard Sedlmeier, Sigrid Wattler and Michael Nehls).
10. Saturation Screening of the Druggable Mammalian Genome (Hector Beltrandelrio, Francis Kern, Thomas Lanthorn, Tamas Oravecz, James Piggott, David Powell, Ramiro Ramirez-Solis, Arthur T. Sands and Brian Zambrowicz).
Index.
