Description

Book Synopsis
MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine.

Table of Contents
Foreword ix
Sir David Baulcombe

Preface xi

Contributors xiii

1 MICRORNAS: A BRIEF INTRODUCTION 1
Charles H. Lawrie

PART I: MICRORNAS AS PHYSIOLOGICAL REGULATORS 25

2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte

3 MICRORNAS AS REGULATORS OF IMMUNITY 41
Donald T. Gracias and Peter D. Katsikis

4 REGULATION OF SENESCENCE BY MICRORNAS 59
Ioannis Grammatikakis and Myriam Gorospe

5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS IMPLICATED IN AGING 77
Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otín, and Andrew J. Ramsay

6 MICRORNAS AND HEMATOPOIESIS 91
Sukhinder K. Sandhu and Ramiro Garzon

7 MICRORNAS IN PLATELET PRODUCTION AND ACTIVATION 101
Leonard C. Edelstein, Srikanth Nagalla, and Paul F. Bray

PART II: MICRORNAS IN INFECTIOUS DISEASE: HOST–PATHOGEN INTERACTIONS 117

8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS INTERACTIONS 119
Aurélie Fender and Sébastien Pfeffer

9 MICRORNA EXPRESSION IN AVIAN HERPESVIRUSES 137
Yongxiu Yao and Venugopal Nair

10 FUNCTION OF HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153
Natalie L. Reynolds, Jon A. Pavelin, and Finn E. Grey

11 INVOLVEMENT OF SMALL NON-CODING RNA IN HIV-1 INFECTION 165
Guihua Sun, John J. Rossi, and Daniela Castanotto

12 MICRORNA IN MALARIA 183
Panote Prapansilp and Gareth D.H. Turner

PART III: CANCER 199

13 THE MICRORNA DECALOGUE OF CANCER INVOLVEMENT 201
Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and George A. Calin

14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223
Eva E. Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and Pedro P. Medina

15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte

16 REGULATION OF HYPOXIA RESPONSES BY MICRORNA EXPRESSION 267
Carme Camps, Adrian L. Harris, and Jiannis Ragoussis

17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio

18 MICRORNAS IN HUMAN PROSTATE CANCER: FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311
Mustafa Ozen and Omer Faruk Karatas

19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel

20 GENETIC VARIATIONS IN MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER SUSCEPTIBILITY AND SURVIVAL 343
Ming Yang and Dongxin Lin

21 MICRORNA IN MYELOPOIESIS AND MYELOID DISORDERS 353
Sara E. Meyer and H. Leighton Grimes

22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC LEUKEMIA 371
Xabier Agirre and Felipe Prósper

23 ROLE OF MIRNAS IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383
Veronica Balatti, Yuri Pekarsky, Lara Rizzotto, and Carlo M. Croce

24 MICRORNA IN B-CELL NON-HODGKIN’S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris

25 MICRORNAS IN DIFFUSE LARGE B-CELL LYMPHOMA 419
Izidore S. Lossos and Alvaro J. Alencar

26 THE ROLE OF MICRORNAS IN HODGKIN’S LYMPHOMA 435
Wouter Plattel, Joost Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg

27 MICRORNA EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449
Cornelis P. Tensen

PART IV: HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463

28 MICRORNAS AND HEREDITARY DISORDERS 465
Matías Morín and Miguel A. Moreno-Pelayo

29 MICRORNAS AND CARDIOVASCULAR DISEASES 477
Koh Ono

30 MICRORNAS AND DIABETES 495
Romano Regazzi

31 MICRORNAS IN LIVER DISEASES 509
Patricia Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M. Banales

32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523
Andreas Junker

33 THE ROLE OF MICRORNAS IN ALZHEIMER’S DISEASE 539
Shahar Barbash and Hermona Soreq

34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553
Aoife Kearney, Javier A. Bravo, and Timothy G. Dinan

PART V: CIRCULATING MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567

35 CIRCULATING MICRORNAS AS NON-INVASIVE BIOMARKERS 569
Heidi Schwarzenbach and Klaus Pantel

36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589
Kasey C. Vickers

37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND METASTASIS IN RENAL CARCINOMA 607
Federica Collino, Cristina Grange, and Giovanni Camussi

PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT PERSPECTIVES AND FUTURE DIRECTIONS 623

38 MICRORNA REGULATION OF CANCER STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625
Can Liu and Dean G. Tang

39 THERAPEUTIC MODULATION OF MICRORNAS 639
Achim Aigner and Hannelore Dassow

40 LOCKED NUCLEIC ACIDS AS MICRORNA THERAPEUTICS 663
Henrik Ørum

Index 673

Micrornas in Medicine

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    A Hardback by Charles H. Lawrie

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      Publisher: John Wiley and Sons Ltd
      Publication Date: 27/12/2013
      ISBN13: 9781118300398, 978-1118300398
      ISBN10: 1118300394
      Also in:
      Biology, life sciences Genetics (non-medical)

      Description

      Book Synopsis
      MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine.

      Table of Contents
      Foreword ix
      Sir David Baulcombe

      Preface xi

      Contributors xiii

      1 MICRORNAS: A BRIEF INTRODUCTION 1
      Charles H. Lawrie

      PART I: MICRORNAS AS PHYSIOLOGICAL REGULATORS 25

      2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
      Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte

      3 MICRORNAS AS REGULATORS OF IMMUNITY 41
      Donald T. Gracias and Peter D. Katsikis

      4 REGULATION OF SENESCENCE BY MICRORNAS 59
      Ioannis Grammatikakis and Myriam Gorospe

      5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS IMPLICATED IN AGING 77
      Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otín, and Andrew J. Ramsay

      6 MICRORNAS AND HEMATOPOIESIS 91
      Sukhinder K. Sandhu and Ramiro Garzon

      7 MICRORNAS IN PLATELET PRODUCTION AND ACTIVATION 101
      Leonard C. Edelstein, Srikanth Nagalla, and Paul F. Bray

      PART II: MICRORNAS IN INFECTIOUS DISEASE: HOST–PATHOGEN INTERACTIONS 117

      8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS INTERACTIONS 119
      Aurélie Fender and Sébastien Pfeffer

      9 MICRORNA EXPRESSION IN AVIAN HERPESVIRUSES 137
      Yongxiu Yao and Venugopal Nair

      10 FUNCTION OF HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153
      Natalie L. Reynolds, Jon A. Pavelin, and Finn E. Grey

      11 INVOLVEMENT OF SMALL NON-CODING RNA IN HIV-1 INFECTION 165
      Guihua Sun, John J. Rossi, and Daniela Castanotto

      12 MICRORNA IN MALARIA 183
      Panote Prapansilp and Gareth D.H. Turner

      PART III: CANCER 199

      13 THE MICRORNA DECALOGUE OF CANCER INVOLVEMENT 201
      Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and George A. Calin

      14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223
      Eva E. Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and Pedro P. Medina

      15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
      Yolanda Sánchez and Maite Huarte

      16 REGULATION OF HYPOXIA RESPONSES BY MICRORNA EXPRESSION 267
      Carme Camps, Adrian L. Harris, and Jiannis Ragoussis

      17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
      Claudia Piovan and Marilena V. Iorio

      18 MICRORNAS IN HUMAN PROSTATE CANCER: FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311
      Mustafa Ozen and Omer Faruk Karatas

      19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
      Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel

      20 GENETIC VARIATIONS IN MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER SUSCEPTIBILITY AND SURVIVAL 343
      Ming Yang and Dongxin Lin

      21 MICRORNA IN MYELOPOIESIS AND MYELOID DISORDERS 353
      Sara E. Meyer and H. Leighton Grimes

      22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC LEUKEMIA 371
      Xabier Agirre and Felipe Prósper

      23 ROLE OF MIRNAS IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383
      Veronica Balatti, Yuri Pekarsky, Lara Rizzotto, and Carlo M. Croce

      24 MICRORNA IN B-CELL NON-HODGKIN’S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
      Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris

      25 MICRORNAS IN DIFFUSE LARGE B-CELL LYMPHOMA 419
      Izidore S. Lossos and Alvaro J. Alencar

      26 THE ROLE OF MICRORNAS IN HODGKIN’S LYMPHOMA 435
      Wouter Plattel, Joost Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg

      27 MICRORNA EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449
      Cornelis P. Tensen

      PART IV: HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463

      28 MICRORNAS AND HEREDITARY DISORDERS 465
      Matías Morín and Miguel A. Moreno-Pelayo

      29 MICRORNAS AND CARDIOVASCULAR DISEASES 477
      Koh Ono

      30 MICRORNAS AND DIABETES 495
      Romano Regazzi

      31 MICRORNAS IN LIVER DISEASES 509
      Patricia Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M. Banales

      32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523
      Andreas Junker

      33 THE ROLE OF MICRORNAS IN ALZHEIMER’S DISEASE 539
      Shahar Barbash and Hermona Soreq

      34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553
      Aoife Kearney, Javier A. Bravo, and Timothy G. Dinan

      PART V: CIRCULATING MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567

      35 CIRCULATING MICRORNAS AS NON-INVASIVE BIOMARKERS 569
      Heidi Schwarzenbach and Klaus Pantel

      36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589
      Kasey C. Vickers

      37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND METASTASIS IN RENAL CARCINOMA 607
      Federica Collino, Cristina Grange, and Giovanni Camussi

      PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT PERSPECTIVES AND FUTURE DIRECTIONS 623

      38 MICRORNA REGULATION OF CANCER STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625
      Can Liu and Dean G. Tang

      39 THERAPEUTIC MODULATION OF MICRORNAS 639
      Achim Aigner and Hannelore Dassow

      40 LOCKED NUCLEIC ACIDS AS MICRORNA THERAPEUTICS 663
      Henrik Ørum

      Index 673

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