Description
Book SynopsisFrom pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
Table of ContentsRole of Nutrition, the Epigenome, and MicroRNAs in Cancer Pathogenesis; Role of MicroRNAs in Metabolic Diseases; Circulating MicroRNAs as Biomarkers of Coeliac Disease and Other Intestinal Pediatric Diseases - Experimental and Bioinformatics Challenges from the Bench to the Bedside; MicroRNAs and Mycobacterial Infections in Humans and Domestic Animals; Regulation and Function of MicroRNAs in Kidney Diseases; Involvement of MicroRNAs in Autoimmune Diseases; MicroRNAs in Ischemic Stroke, Hemorrhagic Stroke, and Traumatic Brain Injury; MicroRNAs as Biomarkers for Neurological Disorders; MicroRNAs in Endocrine Disorders; MicroRNAs in Skin Development, Function and Disorders; MicroRNAs in Haematological Diseases; Discovery and Therapeutic Relevance of Small Molecule Modifiers of MicroRNA Function; MicroRNA-specific Argonaute 2 Protein Inhibitors and AGO Loading Inhibitors; Strategies for Safe and Targeted Delivery of MicroRNA Therapeutics; Modification of Drug Response in Cancer by MicroRNAs; Nanoparticle Delivery of MiRNA in Cancer
