Description
Book SynopsisIn recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarray Innovations: Technology and Experimentation examines the incredibly powerful nature of array technology and the ways in which it can be applied to understanding the genomic basis of disease.
Explores a myriad of applications in use today
This volume explores recent innovations in the microarray field and tracks the evolution of the major platforms currently used. The international panel of contributors presents a survey of the past five years' research and advancements in microarray methods and applications and their usage in drug discovery
Table of Contents
Introduction to Gene Expression Profiling with DNA Microarray Technology. Introduction to Large-Scale Gene Expression Data Analysis. The Statistical Design and Analysis of Gene Expression Data. Laboratory Automation for Microarray Experimentation. How to Evaluate a Microarray Scanner. The Role of Substrates in Microarray Experimentation and How to Choose the Correct Coating for Microarraying. Towards Highly Efficient Automated Hybridizations. Characterization of Microarray Hybridization Stoichiometry. Data Normalization Selection. Methods for Assessing Microarray Performance. Comparison of Different Normalization Methods for Applied Biosystems Expression Array System. A Systematic Comparison of Gene Expression Measurements Across Different Hybridization-Based Technologies. DNA Methylation Arrays: Methods and Analysis. Electronic Microarrays: Progress toward DNA Diagnostics. New Applications for Microarrays. Development of an Oligonucleotide Microarray for Mutational Analysis Using Single or Multiple Sample Hybridization. Development of an Integrated Molecular Diagnostic Test to Identify Respiratory Viruses. Microarrays in Neuroscience. Optimization of Protein Array Fabrication for Establishing High Throughput Ultra-Sensitive Microarray Assays for Cancer Research. Index.
