Description

Book Synopsis
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.

Table of Contents

Contributors xi

Series Preface xix

Volume Preface xxi

PART 1: INTRODUCTION 1

Mechanisms Controlling the Cellular Metal Economy 3
Benjamin A. Gilston and Thomas V. O’Halloran

PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15

The Metallome 17
Vadim N. Gladyshev and Yan Zhang

Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39
Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson

Sparing and Salvaging Metals in Chloroplasts 51
Crysten E. Blaby-Haas and Sabeeha S. Merchant

Fluorescent Probes for Monovalent Copper 65
M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni

Fluorescent Zinc Sensors 85
Amy E. Palmer, Jose G. Miranda and Kyle P. Carter

X-Ray Fluorescence Microscopy 99
James E. Penner-Hahn

PART 3: MOVING METALS IN CELLS 111

Iron and Heme Transport and Trafficking 113
Yvette Y. Yien and Barry H. Paw

Iron in Plants 131
Jessica B. Weng and Mary Lou Guerinot

Transport of Nickel and Cobalt in Prokaryotes 145
Thomas Eitinger

Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155
Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins

Copper Transport in Fungi 163
Simon Labbe, Jude Beaudoin and Raphael Ioannoni

Structural Biology of Copper Transport 175
Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger

Zinc Transporters and Trafficking in Yeast 183
Yi-Hsuan Wu and David J. Eide

Cadmium Transport in Eukaryotes 195
Nathan Smith, Wenzhong Wei and Jaekwon Lee

PART 4: METALS IN REGULATION 207

Metal Specificity of Metallosensors 209
Khadine A. Higgins and David P. Giedroc

Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225
Zhen Ma and John D. Helmann

Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related α-Proteobacteria 237
Mark R. O’Brian

The Iron Starvation Response in Saccharomyces cerevisiae 249
Caroline C. Philpott and Pamela M. Smith

Hepcidin Regulation of Iron Homeostasis 265
Clara Camaschella and Laura Silvestri

NikR: Mechanism and Function in Nickel Homeostasis 277
Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble

Regulation of Copper Homeostasis in Plants 289
Marinus Pilon and Wiebke Tapken

Regulation of Zinc Transport 301
Taiho Kambe

Selenoproteins—Regulation 311
Lucia A. Seale and Marla J. Berry

PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321

Metals in Bacterial Pathogenicity and Immunity 323
Jennifer S. Cavet

Manganese in Neurodegeneration 335
Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner

Iron Sequestration in Immunity 349
Colin Correnti and Roland K. Strong

Molecular Basis of Hemochromatosis 361
Paul J. Schmidt

Copper in Brain and Neurodegeneration 373
Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White

Copper Transporting ATPases in Mammalian Cells 395
Nan Yang and Svetlana Lutsenko

Copper in Immune Cells 409
Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan

Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421
William Self and Sarah Rosario

Resistance Pathways for Metalloids and Toxic Metals 429
Zijuan Liu, Christopher Rensing and Barry P. Rosen

PART 6: COFACTOR ASSEMBLY 443

Fe–S Cluster Biogenesis in Archaea and Bacteria 445
Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten

Mitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters 473
Andrew Dancis and Paul A. Lindahl

[FeFe]-Hydrogenase Cofactor Assembly 491
Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick

[NiFe]-Hydrogenase Cofactor Assembly 507
Basem Soboh and R. Gary Sawers

Copper in Mitochondria 517
Katherine E. Vest and Paul A. Cobine

Mo Cofactor Biosynthesis and Crosstalk with FeS 529
Florian Bittner and Ralf R. Mendel

Nitrogenase Cofactor Assembly 543
Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu

Index 555

Metals in Cells

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    A Hardback by Valeria Culotta, Robert A. Scott

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      Publisher: John Wiley & Sons Inc
      Publication Date: 27/09/2013
      ISBN13: 9781119953234, 978-1119953234
      ISBN10: 1119953235
      Also in:
      Chemistry

      Description

      Book Synopsis
      Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.

      Table of Contents

      Contributors xi

      Series Preface xix

      Volume Preface xxi

      PART 1: INTRODUCTION 1

      Mechanisms Controlling the Cellular Metal Economy 3
      Benjamin A. Gilston and Thomas V. O’Halloran

      PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15

      The Metallome 17
      Vadim N. Gladyshev and Yan Zhang

      Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39
      Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson

      Sparing and Salvaging Metals in Chloroplasts 51
      Crysten E. Blaby-Haas and Sabeeha S. Merchant

      Fluorescent Probes for Monovalent Copper 65
      M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni

      Fluorescent Zinc Sensors 85
      Amy E. Palmer, Jose G. Miranda and Kyle P. Carter

      X-Ray Fluorescence Microscopy 99
      James E. Penner-Hahn

      PART 3: MOVING METALS IN CELLS 111

      Iron and Heme Transport and Trafficking 113
      Yvette Y. Yien and Barry H. Paw

      Iron in Plants 131
      Jessica B. Weng and Mary Lou Guerinot

      Transport of Nickel and Cobalt in Prokaryotes 145
      Thomas Eitinger

      Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155
      Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins

      Copper Transport in Fungi 163
      Simon Labbe, Jude Beaudoin and Raphael Ioannoni

      Structural Biology of Copper Transport 175
      Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger

      Zinc Transporters and Trafficking in Yeast 183
      Yi-Hsuan Wu and David J. Eide

      Cadmium Transport in Eukaryotes 195
      Nathan Smith, Wenzhong Wei and Jaekwon Lee

      PART 4: METALS IN REGULATION 207

      Metal Specificity of Metallosensors 209
      Khadine A. Higgins and David P. Giedroc

      Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225
      Zhen Ma and John D. Helmann

      Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related α-Proteobacteria 237
      Mark R. O’Brian

      The Iron Starvation Response in Saccharomyces cerevisiae 249
      Caroline C. Philpott and Pamela M. Smith

      Hepcidin Regulation of Iron Homeostasis 265
      Clara Camaschella and Laura Silvestri

      NikR: Mechanism and Function in Nickel Homeostasis 277
      Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble

      Regulation of Copper Homeostasis in Plants 289
      Marinus Pilon and Wiebke Tapken

      Regulation of Zinc Transport 301
      Taiho Kambe

      Selenoproteins—Regulation 311
      Lucia A. Seale and Marla J. Berry

      PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321

      Metals in Bacterial Pathogenicity and Immunity 323
      Jennifer S. Cavet

      Manganese in Neurodegeneration 335
      Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner

      Iron Sequestration in Immunity 349
      Colin Correnti and Roland K. Strong

      Molecular Basis of Hemochromatosis 361
      Paul J. Schmidt

      Copper in Brain and Neurodegeneration 373
      Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White

      Copper Transporting ATPases in Mammalian Cells 395
      Nan Yang and Svetlana Lutsenko

      Copper in Immune Cells 409
      Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan

      Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421
      William Self and Sarah Rosario

      Resistance Pathways for Metalloids and Toxic Metals 429
      Zijuan Liu, Christopher Rensing and Barry P. Rosen

      PART 6: COFACTOR ASSEMBLY 443

      Fe–S Cluster Biogenesis in Archaea and Bacteria 445
      Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten

      Mitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters 473
      Andrew Dancis and Paul A. Lindahl

      [FeFe]-Hydrogenase Cofactor Assembly 491
      Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick

      [NiFe]-Hydrogenase Cofactor Assembly 507
      Basem Soboh and R. Gary Sawers

      Copper in Mitochondria 517
      Katherine E. Vest and Paul A. Cobine

      Mo Cofactor Biosynthesis and Crosstalk with FeS 529
      Florian Bittner and Ralf R. Mendel

      Nitrogenase Cofactor Assembly 543
      Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu

      Index 555

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