Description
Book SynopsisThis book describes the events of primary energy transduction in life processes. Life as we know it depends on pumping protons across membranes. New tools to study the protein complexes involved has led to recent intensified progress in the field. Primary Energy Transduction in Biology focusses on recent structural results and new biophysical insights. These have been made possible by recent advances in high-resolution protein structures, in physical techniques to study reactions in real time, and in computational methods to study and refine both structures and their dynamics. Written and edited by leading experts, chapters discuss the latest key questions in cell respiration, photosynthesis, bioenergetics, proton transfer, electron transfer and membrane transport. Biochemists, biophysicists and chemical biologists will find this book an essential resource for a complete understanding of the molecular machines of bioenergetics.
Table of ContentsMaking Maquette Models of Bioenergetic Structures; Structure of Respiratory Complex I: ‘‘Minimal’’ Bacterial and ‘‘De luxe’’ Mammalian Versions; Structure and Function of Respiratory Complex I; Multi-scale Molecular Simulations on Respiratory Complex I; Coupling Hydride Transfer to Proton Pumping: the Swiveling Mechanism of Transhydrogenase; The Na1+-Translocating NADH: Ubiquinone Oxidoreductase (Na1+-NQR); The bc1 Complex: A Physicochemical Retrospective and an Atomistic Prospective; Advances in Understanding Mechanism and Physiology of Cytochromes bc; Life and Death of Cytochrome c Oxidase: Influence of Subunit III on the D pathway, Proton Backflow and Suicide Inactivation; Computational Means of Assessing Proton Pumping in Cytochrome c Oxidase (Complex IV); Water Oxidation by PSII: A Quantum Chemical Approach; Respiratory Supercomplexes in Mitochondria; Structure, Mechanism and Regulation of ATP Synthases
