Description

Book Synopsis
Mannose-binding lectin (MBL) is a plasma protein with an important role in the innate immune system. MBL recognises pathogens through carbohydrate structures present on the surface of a range of pathogenic organisms including viruses, bacteria, fungi and protozoans. These structures may be referred to as pathogen-associated molecular patterns (PAMPs). After binding to PAMPs, MBL promotes C1- and antibody-independent activation of complement, leading to complement-mediated killing and/or phagocytosis. MBL is also known to modulate the secretion of cytokines from macrophages and to mediate the clearance of apoptotic cells as such playing a role in the inflammatory response. This book summarises the actual understanding of human MBL biology and introduces the general aspects of the structure, function and genetics of MBL, as well as an analysis of the role of MBL in the predisposition to clinically relevant diseases.

Mannose-Binding Lectin in the Innate Immune

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    A Paperback / softback by Iara de Messias-Reason, Angelica B W Boldt

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      Publisher: Nova Science Publishers Inc
      Publication Date: Publication Date: 28/05/2009
      ISBN13: 9781606927168, 978-1606927168
      ISBN10: 1606927167

      Description

      Book Synopsis
      Mannose-binding lectin (MBL) is a plasma protein with an important role in the innate immune system. MBL recognises pathogens through carbohydrate structures present on the surface of a range of pathogenic organisms including viruses, bacteria, fungi and protozoans. These structures may be referred to as pathogen-associated molecular patterns (PAMPs). After binding to PAMPs, MBL promotes C1- and antibody-independent activation of complement, leading to complement-mediated killing and/or phagocytosis. MBL is also known to modulate the secretion of cytokines from macrophages and to mediate the clearance of apoptotic cells as such playing a role in the inflammatory response. This book summarises the actual understanding of human MBL biology and introduces the general aspects of the structure, function and genetics of MBL, as well as an analysis of the role of MBL in the predisposition to clinically relevant diseases.

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