Description
Book SynopsisJuvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes.
Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity. This book
Table of Contents
Juvenile Hormones and Juvenoids: A Historical Survey. Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology. Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation. Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite. Roles of Juvenile Hormone Analog Methoprene in Gene Transcription. Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management. Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species. SAR and QSAR Modeling of Juvenile Hormone Mimics. Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila. Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling. Receptor-Guided Structure–Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases. Structural Studies of Juvenile Hormone-Binding Proteins. In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents. Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control. Index.
