Description
Book SynopsisThe field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biological, and environmental sciences.
The authors first explain how kinetic, equilibrium, and anharmonic isotope effects are used to measure the ratio of reaction rates, the ratio between isotopes in thermodynamic equilibrium, and the geometric changes between molecules. The volume describes basic theories, including gas phase, simple condensed phase, small molecule studies, and applications of the Bigeleisen-Mayer theory before covering how isotopes affect molecular geometries, chemical bond breaking, formation and chemical dynamics, and hydrogen transfer. It explores novel, mass-independent isotope effects and problems encountered i
Trade Review
"Kohen and Limbach have produced a massive text that broadly covers the subject of isotope effects in 42 chapters written by experts in the field. Collectively, the chapters demonstrate the very close connection between experiment and theory that is the hallmark of research on isotope effects. …All of the chapters begin with a helpful table of contents, and most have introductory sections that provide excellent background for the subsequent advanced material."
-W. Phillip Huskey, Journal of the American Chemical Society, 2006
"Written by internationally recognized researchers from 13 countries, this volume (42 chapters) brings together a wide scope of different perspectives and practical developments and applications into a comprehensive reference of isotope effects that reflect the most current state-of-the-art."
– In Anticancer Research, September/ October 2007, Vol. 27, No. 5A
Table of ContentsEquilibrium Isotope Effects and Isotope Separation. Condensed Matter and Hydrogen Bond Isotope Effects. Isotope Effects in Chemical Dynamics. Atmospheric, Geologic, and Extraterrestrial Studies. Isotope Effects in Organic Reactions. Kinetic Isotope Effects of Hydrogen Transfer Reactions of Polyatomic Molecules in Condensed Phases. Kinetic Isotope Effects of Hydrogen Transfer Reactions of Complex Systems. Enzyme Mechanisms from Isotope Effects. Hydrogen Bonding and Solvent Isotope Effects in Enzymes.
