Description
Book SynopsisAn in-depth look at cutting-edge research on the body''s innate immune system
Innate immunity is the body''s first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity.
Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medicati
Table of Contents
Preface ix
Contributors xi
Part I Overview of Skin and Muscosal Innate Immunity: History, Ethics, and Science
Chapter 1 Germ Free: Hygiene History and Consuming Antimicrobial and Antiseptic Products 3
Jennifer Tebbe-Grossman and Martha N. Gardner
Chapter 2 Ethical Responsibilities in Formulating, Marketing, and Using Antimicrobial Personal Products 43
Kenneth A. Richman
Chapter 3 Role of Stratum Corneum in Permeability Barrier Function and Antimicrobial Defense 59
Peter M. Elias
Part II Antimicrobial Lipids and Peptides
Chapter 4 Antimicrobial Lipids of the Skin and Oral Mucosa 75
Kim A. Brogden, David R. Drake, Deborah V. Dawson, Jennifer R. Hill, Carol L. Bratt, and Philip W. Wertz
Chapter 5 Resident Microflora and Antimicrobial Peptides of Skin 83
Shamim A. Ansari
Chapter 6 Defensins 109
Neelam Muizzudin
Chapter 7 Antimicrobial Peptides of Skin and Oral Mucosa 117
Whasun O. Chung and Henrik Dommisch
Chapter 8 Vernix Caseosa and Innate Immunity 145
Steven B. Hoath, Vivek Narendran, and Marty O. Visscher
Part III Host Cellular Components of Innate Immunity
Chapter 9 Sentinel Role of Mast Cells in Innate Immunity 173
Zhenping Wang and Anna Di Nardo
Chapter 10 Cellular Immunity of the Skin: Langerhans Cells and Dendritic Cells 195
Karen E. Burke and Niroshana Anandasabapathy
Part IV Innate Immunity Response to Stress and Aging
Chapter 11 Changes in Skin Immunity with Age and Disease 217
Barbara Geusens, Iles Mollet, Chris D. Anderson, Sarah Terras, Michael S. Roberts, and Jo Lambert
Chapter 12 Epidermis as a Sheild from Radiation and Oxidative Stress 259
Giuseppe Valacchi
Chapter 13 The Impact of the Skin’s Innate Immunity by Cosmetic Products Applied to the Skin and Scalp 275
Rudranath Persaud and Thomas Re
Chapter 14 UV-Induced Immunosuppression of Skin 281
Roger L. McMullen
Part V Innate Immunity Microbial Challenges
Chapter 15 Deranged Antimicrobial Barrier in Atopic Dermatitis: Roles of Sphingosine, Hexadecenoic Acid, and Beta-Defensine-2 307
Gangi Imokawa
Chapter 16 Resident Microflora of the Skin and Oral Mucosa 325
David R. Drake
Chapter 17 Corynebacterium Species and Their Role in the Generation of Human Malodor 333
Carol L. Bratt and Nava Dayan
Index 351
