Description
Book SynopsisHuman Population Genetics will provide an introduction to mathematical population genetics, along with relevant examples from human (and some non-human primate) populations, and will also present concepts and methods of population genetics that are specific to the study of human populations.
Trade Review“Relethford’s Human Population Geneticsis a superb attempt at facing the challenges of explaining the basics of population genetics to those with a limited background in evolutionary theory and a fear of the quantitative.” (The Quarterly Review of Biology, 1 September 2014)
“For many students, and likely some instructors, who have found the mathematical underpinnings of evolutionary genetics daunting, this new volume will be a welcome addition to the bookshelf. It is an easy book to recommend either as a primary text in anthropological genetics courses, or as a recommended or adjunct text in upper division/beginning graduate courses in human biology, human genetics, or human evolution.” (American Journal of Physical Anthropology, 19 September 2013)
Table of ContentsForeword vii
Preface ix
1 Genetic, Mathematical, and Anthropological Background 1
I. The Scope of Population Genetics 2
II. Genetics Background 5
III. Principles of Probability 14
IV. The Anthropological Connection 17
V. A Closing Thought 21
2 Hardy–Weinberg Equilibrium 23
I. Genotype and Allele Frequencies 24
II. What is Hardy–Weinberg Equilibrium? 30
III. The Mathematics of Hardy–Weinberg Equilibrium 31
IV. Using Hardy–Weinberg Equilibrium 37
V. Extensions of Hardy–Weinberg Equilibrium 40
VI. Hardy–Weinberg Equilibrium and Evolution 44
VII. Summary 45
3 Inbreeding 49
I. Quantifying Inbreeding 51
II. Population Genetics and Inbreeding 62
III. Inbreeding in Human Populations 65
IV. Summary 75
4 Mutation 77
I. The Nature of Mutations 77
II. Models of Mutation 81
III. Mutational History and Anthropological Questions 88
IV. Summary 96
5 Genetic Drift 101
I. What is Genetic Drift? 102
II. Genetic Drift and Population Size 112
III. Effects on Genetic Variation 120
IV. Mutation and Genetic Drift 121
V. Coalescent Theory 125
VI. Summary 131
6 Models of Natural Selection 139
I. How Does Natural Selection Work? 140
II. A General Model of Natural Selection 145
III. Types of Natural Selection 147
IV. Other Aspects of Selection 160
V. Summary 167
7 Natural Selection in Human Populations 181
I. Case Studies of Natural Selection in Human Populations 182
II. Are Humans Still EvolVIng? 198
III. Summary 203
8 Gene Flow 205
I. The Evolutionary Impact of Gene Flow 206
II. Models of Gene Flow 208
III. Gene Flow and Genetic Drift 213
IV. Estimating Admixture in Human Populations 226
V. Summary 230
9 Human Population Structure and History 237
I. Case Studies of Human Population Structure 238
II. The Origin of Modern Humans 242
III. Case Studies of Population Origins 247
IV. Summary 255
Glossary 257
References 267
Index 279
