Description
Book SynopsisSince the publication of the first edition of the Handbook of Human Immunology in 1997, major scientific achievements have directly contributed to an increased understanding of the complexities of the human immune system in health and disease. Whether as a result of the sequencing of the entire human genome, or of technological advancements, several new components of the immune system have been revealed, along with new technologies for their measurement and evaluation.
Major breakthroughs in the field include an increase in the number of recognized clusters of differentiation on the surface of leukocytes and associated cells, the establishment of a chemokine and chemokine receptor nomenclature system, the discovery of more than 30 lymphokines, and humanized monoclonal antibody therapy as a staple of pharmacologic armamentarium
Modeling the previous edition, the text begins with an overview of the immune system, focusing on the role of cell receptors, accessory m
Trade Review
"This is a well-written, multi-author reference book which will be useful for dipping into to ascertain certain facts, while at the same time being well-written enough to sit down and read. This book would be useful for anyone engaged in clinical immunological research and for routine immunology labs."
Andy Heath, Society for General Microbiology, Feb. 2009
Table of ContentsOverview of Immunity. Statistics of Immunological Testing. Human Immunoglobulins. The Complement System. Cellular Immunology: Monitoring of Immune Therapies. Understanding Clinical Flow Cytometry. Leukemia and Lymphoma Immunophenotyping and Cytogenetics. Guidelines for the Use of Flow Cytometry in the Management of Patients Infected with the Human Immunodeficiency Virus Type-1 and the Acquired Immunodeficiency Syndrome. Role of Flow Cytometry in the Diagnosis and Monitoring .of Primary Immunodeficiency Disease. Detection and Characterization of the T-Cell Receptor Repertoire. Human Leukocyte Differentiation Antigens, Cluster of Differentiation: Past, Present, and Future. Immunologic Diagnosis of Autoimmunity. Autoimmune and Immune-Mediated Diseases of the Gastrointestinal. Serologic Testing for Infectious Diseases. Cytokines; Regulators of Immune Responses and Key Therapeutic Targets. Measuring Human Cytokines. The Human Major Histocompatibility Complex and .DNA-Based Typing of Human Lymphocyte Antigens (HLA) for Transplantation. Relevance of Antibody Screening and Crossmatching in Solid Organ, Hematopoietic Stem Cell Transplantation, and Blood Transfusion. Functional Assessment of Immunosuppression: Monitoring Posttransplant Alloreactivity with Flow Cytometric Mixed Lymphocyte Cocultures.
