Description
Book SynopsisWhile mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today''s lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met.
To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models.
The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, includi
Trade Review"…I found an oasis of practical information making this book well worth obtaining. …clear and concise …descriptions of cryopreservation techniques for embryos, gametes, and ovarian tissue. Everything you need to know was laid out in outline form with illustrations and references."
--Mark Klinger for Laboratory Animal Practitioner, Vol. 39, No. 1, March 2006
"The Genetically Engineered Mice Handbook effectively summarizes commonly used and emerging technologies to generate, characterize, and conduct research on genetically engineered mice . . . provides a broad multinational perspective on the use of genetically engineered mice for functional genomics research . . . well organized and highly informative. . ."
– Dr. Cory Brayton, School of Medicine, Johns Hopkins University, in Veterinary Pathology, 2007, Vol. 44, No. 4
Table of ContentsIntroduction and Overview. Creating Mutant Mice as Biomedical Tools. Legal Aspects of Mutant and Inbred Laboratory Mice. Repositories for Mutant Laboratory Mice. Information Repositories: International Databases. Approaches to Analysis of Mutant Laboratory Mice. Mouse Models for Developmental Biology. Infectious Diseases: Monitoring of Laboratory Mouse Colonies and Use in Genetic Engineering. Summary.
