Description
Book SynopsisThis book combines discursive chapters that present the latest progress in molecular biology, drug discovery, organ-tissue engineering, and related fields, with a number of descriptive chapters on methods, protocols, and case studies.
Table of ContentsPart I: Molecular Genetics and Genomics
1. Gene Alterations Induced by Glutamine (Q) Encoding CAG Repeats Associated with Neurodegeneration
Gundappa Saha, Sukanya Ghosh, Vikash Kumar Dubey, and Prakash Saudagar
2. Latest Trends in Nucleic Acid-Based Engineering Techniques Applied to Precision Medicine Glaucia C. Pereira
3. Nanotechnology Driven Delivery Systems in Inoculation Therapies
Glaucia C. Pereira
Part II: Molecular Biology in Drug Development and Therapeutics
4. Chronic Kidney Disease: Challenges in Translational Medicine
Bruno Freire Botelho, André Luis Barreira, Maurilo Leite Jr., and Marcelo Marcos Morales
5. Mass Spectroscopy as an Analytical Tool to Harness the Production of Secondary Plant Metabolites: The Way Forward for Drug Discovery
Faheem Ahmad and Hera Nadeem
6. Assessing the Challenges of Nanotechnology-Driven Targeted Therapies: Development of Magnetically Directed Vectors for Targeted Cancer Therapies and Beyond
Matthew T. Bryan
Part III: Molecular, Cellular, Tissue Engineering, and AI-Based Computational Design
7. Advances in Regenerative Medicine and Biomaterials
Şükran Şeker, Ayşe Eser Elçin, and Yaşar Murat Elçin
8. A Brief Review of Plant Cell Transfection, Gene Transcript Expression, and Genotypic Integration for Enhancing Compound Production
Munish Sharma, Sakshi Bhushan, Deepak Sharma, Sanjana Kaul, and Manoj K. Dhar
9. A Review of Stem Cell Technology Targeting Hepatocyte Growth as an Alternative to Organ Transplantation
Ernesto Goulart
10. Novel Nanotechnology-Driven Prototypes for AI-Enriched Implanted Prosthetics Following Organ Failure
Glaucia C. Pereira
Part IV: Methods and Protocols
11. Simplified CRISPR-Mediated DNA Editing in Multicellular Eukaryotes
Ritesh Kumar, Kartikeya Tiwari, and Prakash Saudagar
12. Design of SaCas9-HF for In Vivo Gene Therapy
Kartikeya Tiwari, Ritesh Kumar, and Prakash Saudagar
13. Stem Cell Technology in Organ Transplantation: A Novel Method for 3D Bioprinting Functional and Stable Liver Grafts Using Human iPS-Derived Cells
Ernesto Goulart
14. In Vitro Assay for the Assessment of Oxygen Depletion Triggers in Human Cell Lines, Associated with Improving Responses to Cancer Therapy
Kartikeya Tiwari, Ritesh Kumar, Gundappa Saha, and Prakash Saudagar
15. The Use of 99mTc-Labeled Stem Cells for Evaluation of Chronic Kidney Disease
Bianca Gutfilen, Sergio Augusto Lopes de Souza, and Marcelo Marcos Morales
16. An Automated Strategy to Handle Antigenic Variability in Immunization Protocols, Part I: Nanopore Sequencing of Infectious Agent Variants
Glaucia C. Pereira
17. An Automated Strategy to Handle Antigenic Variability in Immunization Protocols, Part II: In Vitro Transcribed mRNA Vector Design for Inoculation Against Infectious Agent Variants
Glaucia C. Pereira
