Description
Book SynopsisDesigning artificial systems with catalytic efficiencies to rival those of natural enzymes is one of the great challenges facing science today. Our current level of understanding fails the basic, practical test - designing and making artificial systems with catalytic efficiencies to rival those of natural enzymes. Chemists and bio-scientists are well aware of this problem, and artificial enzymes have been a hot topic for many years. However, until now, there has been no book devoted specifically to this subject. This is the first book to provide a critical introduction to, and overview of, this exciting area. It is aimed at students and more senior researchers with specialist or general interests in the field. The book starts with a systematic overview of the most important properties of natural enzymes, with special emphasis on mechanisms and efficiency of catalysis. This is followed by a summary of the mechanisms involved in the major classes of reaction they catalyze, and spells out
Trade Review"The organizational is logical, progressing from an introduction of the principles of catalysis through model systems to more sophisticated efforts that include biochemical methods to improve the catalytic function of proteins.""The coverage of topics is broad rather than deep, consistent with the authors' goal of introducing enzyme models to a wide readership.""Overall this is a valuable mongraph, particularly for those who are reasonably conversant with the underlying principles of catalysis. The text is very well written and the coverage of the topic is sufficient to give a broad overview of the field." * JACS, 2010, 132, 3637-3638 *
"Enzymes and how they work is a fascinating topic not only for chemists and biochemists, but for scientists in general, and the current importance of "green" and sustainable chemistry has not made the topic any less interesting.""...an excellent text for those who wish to enter or work in the field of enzyme mimicry.""Anthony Kirby is a first-rate expert in the area and, together with his younger colleagues, leads one through it with care and thoroughness." * ChemBioChem, 2010, 11, 581 - 583 *
Table of ContentsIntroduction Evaluation Classification by model system Classification by reaction Problems Glossary Index
