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Book Synopsis
The fluoropyrimidine 5-fluorouracil (5-FU), an antimetabolite drug, works by being incorporated in the RNA and DNA and by the inhibition of the nucleotide synthetic enzyme thymidylate synthase. It is widely used in the treatment of a range of cancers, including gastrointestinal, head and neck, and breast cancers. In this book, the authors present current research in the study of the synthesis, health effects and role in chemotherapy of fluorouracil. Topics discussed include the antiproliferative activities, cell-cycle regulation, apoptosis and cellular differentiation of acyclic 5-fluorouracil O, N-Acetals; 5-fluorouracil and its immunotoxicity and side effects; 5-fluorouracil application in the management of bleb failure; and cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma.

Fluorouracil: Synthesis, Health Effects & Role in

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    A Hardback by Alberto C Dário Longinho, Sebastiao E Britto Dobreiro

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      View other formats and editions of Fluorouracil: Synthesis, Health Effects & Role in by Alberto C Dário Longinho

      Publisher: Nova Science Publishers Inc
      Publication Date: Publication Date: 09/10/2012
      ISBN13: 9781620819708, 978-1620819708
      ISBN10: 1620819708

      Description

      Book Synopsis
      The fluoropyrimidine 5-fluorouracil (5-FU), an antimetabolite drug, works by being incorporated in the RNA and DNA and by the inhibition of the nucleotide synthetic enzyme thymidylate synthase. It is widely used in the treatment of a range of cancers, including gastrointestinal, head and neck, and breast cancers. In this book, the authors present current research in the study of the synthesis, health effects and role in chemotherapy of fluorouracil. Topics discussed include the antiproliferative activities, cell-cycle regulation, apoptosis and cellular differentiation of acyclic 5-fluorouracil O, N-Acetals; 5-fluorouracil and its immunotoxicity and side effects; 5-fluorouracil application in the management of bleb failure; and cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma.

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