Description
Book SynopsisThis book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns.
Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions.
The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders.
Each topic explains new advances, all current treatment protocols, new drugs, and management approaches.
Chapters are further enhanced by clinical images and tables.
Key points
- Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns
- Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches
- Includes discussion on neonatal malignancies and blood transfusion
- Highly illustrated with clinical images and tables
Table of ContentsSection 1: Fetal Hematology and Antenatal Diagnosis of Hematological Disorders
- Physiology of Hematopoiesis
- Developmental Hemostasis and Physiology ofHemostasis in the Fetus and the Newborn
- Granulocytes: Development and Physiology
- Developmental Aspects of Platelets
- Fetal Anemia
- Thalassemia in the Fetus: Prenatal Diagnosis
- Genetic Counseling for Hematological Disorders
- Fetal Hematological Disorders: Future Ahead
Section 2: RBC Disorders and Anemia in Newborn
- Developmental Erythropoiesis
- Normal Hematological Values and Variation in Newborn Periodwith Special Reference to Hb and RBC Parameters
- Effect of Nutritional Deficiency Anemia duringPregnancy on Fetus and Newborn
- Anemia of Prematurity
- Clinical Aspect of Immune Hemolytic Disease of Newborn
- Laboratory Management of ABO and Rh HemolyticDisease of the Fetus and Newborn
- Nonimmune Hemolytic Anemia
- Inherited Bone Marrow Failure Syndromes
- Polycythemia and Hyperviscosity Syndrome in Newborn
Section 3: Coagulation Disorders in Newborn
- Congenital Coagulation Disorders in the Neonate
- Vitamin K Deficiency Bleeding
- Disseminated Intravascular Coagulation in the Neonatal Period
- Thrombophilia in Newborns
Section 4: Platelets, Platelet Disorders and Approach to Bleeding in Newborn
- Approach to Neonatal Thrombocytopenia
- Neonatal Thrombocytopenia: Syndromic Causes
- Qualitative Platelet Disorders
- Approach to a Bleeding Neonate
Section 5: Neutrophil Disorders
- Neutrophilia
- Important Causes of Neutropenia Including Inherited Conditions:Diagnosis and Work-up
- Neutrophil Function Defects
- Management of Neutropenia and Infections
Section 6: Fetal and Neonatal Malignancy
- Cancers in Infants
- Neonatal Leukemia
- Neonatal Liver Tumor
- Neuroblastoma
- Renal Tumors in Neonates
- Neonatal Soft Tissue Sarcomas
- Fetal and Neonatal Germ Cell Tumors
- Retinoblastoma and its Prenatal Screening
- Pharmacology of Anticancer Drugs in Neonate
- Challenges in Neonatal Malignancies
Section 7: Blood Transfusion (Component Therapy) and Supportive Therapy
- Cellular Blood Components in Neonatal Practice
- Plasma and Its Derivatives
- Technical Aspects of Blood and Blood Components Transfusion including Leukodepletion and Irradiation
- Risk of Transfusion in Fetus and Neonate
- Hematological Growth Factors as Supportive Therapy
Section 8: Immunological Disorders
- Introduction to Immunology
- Fetal and Neonatal Immunity
- Infections in Neonatal Period: Primary Immunodeficiency Perspective
- Approach to Newborns with Immunodeficiency
- Neutrophil Functions and Disorders of Neutrophils in Newborns
- Combined T- and B-Cell Defects
- Primary Antibody Deficiencies
- Combined Immunodeficiencies with Associated or Syndromic Features
- Immune Dysregulation Syndromes
- Complement Disorders
- Autoinflammatory Syndromes
- Management of Specific Immunodeficiencies
- Neonatal Screening and Prenatal Diagnosis of Primary Immunodeficiency Disorders
Index
