Description
Book SynopsisEquilibria and Kinetics of Biological Macromolecules provides readers with an understanding of the biophysics of macromolecules.
Table of ContentsPreface xix
Acknowledgments xxi
PART 1 BASIC PRINCIPLES 1
1. Thermodynamics 3
2. Four Basic Quantum Mechanical Models of Nuclear and Electronic Motion: A Synopsis 35
3. Molecular Structure and Interactions 51
4. Water and the Hydrophobic Effect 77
PART 2 STATISTICAL MECHANICS: THE MOLECULAR BASIS OF THERMODYNAMICS 91
5. The Molecular Partition Function 93
6. System Ensembles and Partition Functions 111
7. Sampling Molecular Systems with Simulations 137
PART 3 BINDING TO MACROMOLECULES 161
8. Binding Equilibria 163
9. Thermodynamics of Molecular Interactions 185
10. Elements of Statistical Mechanics of Liquids and Solutions 197
11. Analysis of Binding Equilibria in Terms of Partition Functions 213
12. Coupled Equilibria 223
13. Allosteric Function 239
14. Charged Groups: Binding of Hydrogen Ions, Solvation, and Charge–Charge Interactions 255
PART 4 CONFORMATIONAL STABILITY AND CONFORMATION CHANGE 277
15. Some Elements of Polymer Physics 279
16. Helix-Coil Equilibria 291
17. Protein Unfolding Equilibria 311
18. Elasticity of Biological Materials 347
PART 5 KINETICS AND IRREVERSIBLE PROCESSES 357
19. Kinetics 359
20. Kinetics of Protein Folding 389
21. Irreversible and Stochastic Processes 415
APPENDICES 437
Index 491
