Description
Book SynopsisThis is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice.
Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control.
Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy.
Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.
Table of ContentsTable of Contents:
Section A: Technology and Science of Electroporation: Fundamentals
1. Electroporation: Technology and Science --- Marie-Pierre Rols*, Muriel Golzio and Justin Teissié
2. Electrodes and electric field distribution in clinical practice - Helena Cindrič, Damijan Miklavčič
Section B: Therapeutic Applications with Electroporation in Veterinary Oncology Practice
3. Electrochemotherapy in Veterinary Oncology - Prof. dr. Nataša Tozon, Nina Milevoj, Joseph Impellizeri
4. Treating Mast Cell Tumors with Electrochemotherapy - Petra Simčič, Alessio Pierini, and George Lubas
5. Electrochemotherapy for the treatment of transitional cell carcinoma in dogs - Rangel M M M*, Suzuki D O H **
6. Calcium electroporation in veterinary medicine - Stine K. Frandsen, Martin S. Thoefner and Julie Gehl
7. Irreversible Electroporation Applications - Dervisis, Rafael V. Davalos, John H. Rossmeisl
8. Electrochemotherapy as a multi-modality component of cancer treatment- combinations with surgery, radiation therapy and chemotherapy - Matias Tellado, Felipe Maglietti, Joseph Impellizeri
Section C: Gene-Electrotransfer and Immunotherapy Applications with Electroporation
9. Gene Electrotransfer---Richard Heller, Loree Heller
10. Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer- Antonella Conforti and Luigi Aurisicchio and Joseph Impellizeri
11. Interleukin-12 gene electrotransfer in veterinary oncology - UrsaTratarLampreht, NatasaTozon, Nina Milevoj, Gregor Sersa, Ana Nemec, KatjaUrsic, Maja Cemazar
12. Canine Melanoma and Osteosarcoma Immunotherapy by means of in vivo DNA Electroporation - Lidia Tarone, Paolo Buracco, Federica Cavallo1 & Federica Riccardo
Section D: Evolution of the Field and New Applications with Electroporation-Based Treatments: Outlook
13. Electrodes for Unique Anatomical Access in Electroporation--- Maglietti F, Tellado M,Impellizeri J
14. New Electrodes and Treatment Planning for deep-seated and intraluminal localized tumors - Roberta Fusco, Valeria D’Alessio, Francesco Izzo, Raffaele Palaia, Ruggero Cadossi
15. Advancing Electroporation Systems - Roberta Fusco, Elio Di Bernardo, Valeria D’Alessio, Ruggero Cadossi, Matteo Cadossi
