Description
Book SynopsisUnderstanding the dopamine transporter can lead to new therapies for neurological disorders
This book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT''s role in diseases such as Parkinson''s, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.
This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, Dopamine Transporters: Chemistry, Biology, and Pharmacology:
Trade Review
"Much of what will be accomplished in the coming years will require an understanding of the issues and tools presented here. No doubt, those focused on other synaptic transporters will be jealous of this resource and should demand companion volumes." (The Quarterly Review of Biology, March 2010)
"The book is well written and the chapters are well illustrated where appropriate. It is a valuable addition to the bookshelf of anyone interested in dopaminergic neurotransmission." (Journal of Medicinal Chemistry, March 2009)
Table of ContentsContributors.
Preface.
Part I: Biochemistry and Molecular Biology.
Chapter 1: The Dopamine Transporter: An Anatomical Perspective (Hilary R. Smith, Thomas J. Beveridge, Colleen A. Hanlon, Linda J. Porrino).
Chapter 2: Dopamine Transporter, Disease States and Pathology (Deborah C. Mash).
Chapter 3: Cloning and Genetic Analysis of Dopamine Transporters (David J. Vandenbergh).
Chapter 4: Molecular Structure and Composition of Dopamine Transporters (M. Laura Parnas and Roxanne A. Vaughan).
Chapter 5: Electrochemical Characterization of Dopamine Transporters (Evgeny A. Budygin and Sara R. Jones).
Part II: Medicinal Chemistry.
Chapter 6: Tropane-Based Dopamine Transporter-uptake Inhibitors (Scott P. Runyon and F. Ivy Carroll).
Chapter 7: The Benztropines: Atypical Dopamine-Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter (Amy Hauck Newman and Jonathan L. Katz).
Chapter 8. Structure-Activity Relationship of GBR 12909 Ligands (Thomas E. Prisinzano and Kenner C. Rice).
Chapter 9: Structure-Activity Relationship Study of Piperidine Derivatives for Dopamine Transporters (Prashant S. Kharkar, Maarten E. A. Reith, and Aloke K. Dutta).
Chapter 10: Non-Nitrogen-Containing Dopamine Transporter-Uptake Inhibitors (Peter C. Meltzer).
Chapter 11: Dopamine-Releasing Agents (Bruce E. Blough).
Part III: Pharmacology.
Chapter 12: PET/SPECT Imaging Studies of the Plasma Membrane Dopamine Transporter. (Paul Cumming, Weiguo Ye, Dean F. Wong).
Chapter 13: In Vitro Studies of Dopamine Transporter Function and Regulation (Brian R. Hoover, Bruce H. Mandt and Nancy R. Zahniser).
Chapter 14: In Vivo Studies of Dopamine Transporter Function (Jane B. Acri).
Index.
