Description

Book Synopsis
This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development.

Trade Review

“The text is well-written and includes extensive references.” (Book News, 1 April 2012)



Table of Contents
PREFACE ix

CONTRIBUTORS xi

PART I FUNDAMENTAL CONCEPTS 1

1. Current Needs for New Therapeutic Agents and Discovery Strategies—A Systems Pharmacology Approach 3
Sophie C. Desbiens and David H. Farb

2. Target Selection in Drug Discovery 25
Charles F. Albright

3. New Drug Applications 35
John S. McInnes and Donald O. Beers

4. From Concept to the Clinics: Development of Cancer Therapeutics 47
Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary

5. Development of Countermeasures for Bioterrorism in the United States 73
Gregory H. Levine and Jeffrey I. Handwerker

6. Development and Application of Conformation-Selective Integrin Antibodies 91
Nathan S. Astrof, Dan Peer, and Motomu Shimaoka

7. Pain Management Market Overview 113
Anita Holdcroft

8. Antiviral Market Overview 127
Anita Arora, Natalia Mendoza, and Stephen K. Tyring

PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145

9. High-Throughput Screening for Small-Molecule Drug Discovery 147
C. Parker and J.-H. Zhang

10. Mass Spectrometry 181
Robert D. English and Anthony M. Haag

11. Molecular Screening for Therapeutic Agents 207
R. Damoiseaux

12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241
Zhengdong Cheng

13. Development of Antimicrobial Peptides as Therapeutic Agents 285
Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant

14. Antibodies for Human Diseases 359
Guo-Liang Yu and Jian Ni

15. Combinatorial Compounds and Drug Discovery 399
James C. Bigelow

16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413
David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim

17. RNAi-Mediated Therapeutics 425
Nuria Morral and Scott R. Witting

18. Crystallography 445
Carl H. Schwalbe

19. PEGylation 463
Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal

20. Gold Standard Animal Models 517
Carol Casteneda and Michael S. LaPointe

21. Discovery of Vaccine Adjuvants 533
Fiona A. Sharp and Ed C. Lavelle

22. Oral Delivery of Macromolecules for the Development of Therapeutic Agents 547
Hye J. Lee and Chanmi Choi

23. Aerosol Drug Delivery to the Lungs 565
Andrew R. Martin and Warren H. Finlay

24. Resistance to Antiplatelet Theraphy 589
Paul A. Gurbel, Udaya S. Tantry, and Mark J. Antonino

25. Antibiotic Development 611
Robert L. Bettiker and Jason C. Gallagher

PART III THERAPEUTIC TOPICS 629

26. Antimicrobial Resistance in Biofi lms: A Sticky Situation 631
Shu Yeong Queck and Michael Otto

27. Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris) 645
Byungse Suh and Rafi k Samuel

28. Anti-Inflammatory Therapeutics 655
Marion M. Chan and Dunne Fong

29. Anti-Inflammatory/Analgesics: An In-depth Look at p38 MAP Kinases 673
Kelly L. Brown

30. Cardiovascular Disease: In-Depth Look 707
Nicholas B. Norgard and Mazen Abu-Fadel

31. Ezetimibe and Cholesterol Absorption 723
Stefan Oswald and Werner Siegmund

32. Cardiology—In-Depth Look: Kinases as Therapeutic Targets in the Heart 743
Karin Mauer and J. Emilio Exaire

33. Statins in the Reduction of Cardiovascular Events 773
Rajesh Sachdeva, Bradley Hughes, and Jawahar L. Mehta

34. Cardiology—In-Depth Look: Advances in Antiplatelet Theraphy 785
Karin Mauer and Jorge F. Saucedo

35. Gastrointestinal Disorders: A Focus on Acid-Suppressive Agents 813
Brian Hemstreet

36. Pharmacology of Vasopressin and the Renin—Angiotension—Aldosterone System 825
Elizabeth J. Brant and Julian L. Seifter

37. New Drugs and Nutaceutical in the Treatment of Osteoarthristis 847
Y. Henrotin and J. Y. Reginster

38. Development of Anticytokine Agents for Rheumatoid Arthritis 881
Jonathan Sherlock, Christopher D. Buckley, and Karim Raza

39. Overview of CNS Neuropharmaceuticals 897
Tauser Roxana-Georgiana and Antohe Dan-Stefan

40. Thinking Outside the Box in Alzheimer Disease Treatment 929
Rudy J. Castellani, Michael W. Marlatt, Akihiko Nunomura, Paula I. Moreira, Hyoung-Gon Lee, Gemma Casadesus, Xiogwei Zhu, George Perry, and Mark A, Smith

41. Neurotrophic Factors as Novel Therapeutic Targets 943
Stephen D. Skaper

42. Oncology 963
Arkadiusz Z. Dudek and Steven F. Powell

43. Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia 999
Muhammad Mansoor Alam and Moshe Talpaz

44. Aromatase Inhibitors for Breast Cancer 1011
Akm Hossain and Jame Abraham

45. Evolution of Selective Estrogen and Androgen Receptor Modulators: Status of Current Therapy and New Drug Development 1019
Gregory T. Wurz and Michael W. DeGregorio

46. In-Depth Look: anti-TNF-α Therapies 1045
Satadal Chatterjee and Shobhan Gaddameedhi

47. Development of Therapeutic Agents: The Maternal—Fetal Perspective 1093
C. Gedeon, F. Garcia Bournissen and G. Koren

48. History of Antipsychotic Drug Development 1111
Shankar S. Gollapudi and Rajan Radhakrishnan

49. Radiopharmaceuticals and Medical Imaging: Development of Radioimmumoconjugates for Radioimmunoimaging and Radioimmunotherapy of Malignant Diseases 1137
Gang Niu and Xiaoyuan Chen

50. Therapeutic Drug Development for Kidney Diseases 1159
Mitchell H. Rosner, Joshua King, and Peter Monteleone

51. Targeting Chemokines and Angiogenesis in Arthritis 1185
Zoltan Szekaneez and Alisa E Koch

52. Development of Therapeutic Agents: Methods and Approaches in the Development of Vaccines against Protozoan Parasites 1207
Catherine Ivory and Kris Chadee

53. Toxicology 1221
John H. Duffus

54. The Development of Phosphodiesterase 4 Inhibitors for Allergic and Nonallergic Infl ammatory Diseases of the Airways 1233
Mark A. Giembycz

INDEX 1251

Development of Therapeutic Agents Handbook

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      Publisher: John Wiley & Sons Inc
      Publication Date: 06/01/2012
      ISBN13: 9780471213857, 978-0471213857
      ISBN10: 0471213853
      Also in:
      Chemistry

      Description

      Book Synopsis
      This book is a one-stop compendium of up-to-date concepts, approaches, methodologies, and limitations in drug development and therapeutics. It provides researchers with a thorough reference focusing on applications, practical methods, and techniques to facilitate new drug development.

      Trade Review

      “The text is well-written and includes extensive references.” (Book News, 1 April 2012)



      Table of Contents
      PREFACE ix

      CONTRIBUTORS xi

      PART I FUNDAMENTAL CONCEPTS 1

      1. Current Needs for New Therapeutic Agents and Discovery Strategies—A Systems Pharmacology Approach 3
      Sophie C. Desbiens and David H. Farb

      2. Target Selection in Drug Discovery 25
      Charles F. Albright

      3. New Drug Applications 35
      John S. McInnes and Donald O. Beers

      4. From Concept to the Clinics: Development of Cancer Therapeutics 47
      Balveen Kaur, Gregory B. Lesinski, and Abhik Ray Chaudhary

      5. Development of Countermeasures for Bioterrorism in the United States 73
      Gregory H. Levine and Jeffrey I. Handwerker

      6. Development and Application of Conformation-Selective Integrin Antibodies 91
      Nathan S. Astrof, Dan Peer, and Motomu Shimaoka

      7. Pain Management Market Overview 113
      Anita Holdcroft

      8. Antiviral Market Overview 127
      Anita Arora, Natalia Mendoza, and Stephen K. Tyring

      PART II METHODS AND TECHNIQUES IN DRUG DISCOVERY AND DEVELOPMENT 145

      9. High-Throughput Screening for Small-Molecule Drug Discovery 147
      C. Parker and J.-H. Zhang

      10. Mass Spectrometry 181
      Robert D. English and Anthony M. Haag

      11. Molecular Screening for Therapeutic Agents 207
      R. Damoiseaux

      12. Accelerator Mass Spectrometry and Positron Emission Tomography in Human Microdosing 241
      Zhengdong Cheng

      13. Development of Antimicrobial Peptides as Therapeutic Agents 285
      Robert S. Hodges, Ziqing Jiang, James Whitehurst, and Colin T. Mant

      14. Antibodies for Human Diseases 359
      Guo-Liang Yu and Jian Ni

      15. Combinatorial Compounds and Drug Discovery 399
      James C. Bigelow

      16. Locoregional Chemoradiotherapy of Cancer Using Hydrogel 413
      David J. Yang, Ali Azhdarinia, Hiroaki Kurihara, and E. Edmund Kim

      17. RNAi-Mediated Therapeutics 425
      Nuria Morral and Scott R. Witting

      18. Crystallography 445
      Carl H. Schwalbe

      19. PEGylation 463
      Sanju Dhawan, Deepak N. Kapoor, Rishi Kapil, Mano Kumarj, and Ankur Bansal

      20. Gold Standard Animal Models 517
      Carol Casteneda and Michael S. LaPointe

      21. Discovery of Vaccine Adjuvants 533
      Fiona A. Sharp and Ed C. Lavelle

      22. Oral Delivery of Macromolecules for the Development of Therapeutic Agents 547
      Hye J. Lee and Chanmi Choi

      23. Aerosol Drug Delivery to the Lungs 565
      Andrew R. Martin and Warren H. Finlay

      24. Resistance to Antiplatelet Theraphy 589
      Paul A. Gurbel, Udaya S. Tantry, and Mark J. Antonino

      25. Antibiotic Development 611
      Robert L. Bettiker and Jason C. Gallagher

      PART III THERAPEUTIC TOPICS 629

      26. Antimicrobial Resistance in Biofi lms: A Sticky Situation 631
      Shu Yeong Queck and Michael Otto

      27. Drotrecogin Alfa Activated (Recombinant Human Activated Protein C, Xigris) 645
      Byungse Suh and Rafi k Samuel

      28. Anti-Inflammatory Therapeutics 655
      Marion M. Chan and Dunne Fong

      29. Anti-Inflammatory/Analgesics: An In-depth Look at p38 MAP Kinases 673
      Kelly L. Brown

      30. Cardiovascular Disease: In-Depth Look 707
      Nicholas B. Norgard and Mazen Abu-Fadel

      31. Ezetimibe and Cholesterol Absorption 723
      Stefan Oswald and Werner Siegmund

      32. Cardiology—In-Depth Look: Kinases as Therapeutic Targets in the Heart 743
      Karin Mauer and J. Emilio Exaire

      33. Statins in the Reduction of Cardiovascular Events 773
      Rajesh Sachdeva, Bradley Hughes, and Jawahar L. Mehta

      34. Cardiology—In-Depth Look: Advances in Antiplatelet Theraphy 785
      Karin Mauer and Jorge F. Saucedo

      35. Gastrointestinal Disorders: A Focus on Acid-Suppressive Agents 813
      Brian Hemstreet

      36. Pharmacology of Vasopressin and the Renin—Angiotension—Aldosterone System 825
      Elizabeth J. Brant and Julian L. Seifter

      37. New Drugs and Nutaceutical in the Treatment of Osteoarthristis 847
      Y. Henrotin and J. Y. Reginster

      38. Development of Anticytokine Agents for Rheumatoid Arthritis 881
      Jonathan Sherlock, Christopher D. Buckley, and Karim Raza

      39. Overview of CNS Neuropharmaceuticals 897
      Tauser Roxana-Georgiana and Antohe Dan-Stefan

      40. Thinking Outside the Box in Alzheimer Disease Treatment 929
      Rudy J. Castellani, Michael W. Marlatt, Akihiko Nunomura, Paula I. Moreira, Hyoung-Gon Lee, Gemma Casadesus, Xiogwei Zhu, George Perry, and Mark A, Smith

      41. Neurotrophic Factors as Novel Therapeutic Targets 943
      Stephen D. Skaper

      42. Oncology 963
      Arkadiusz Z. Dudek and Steven F. Powell

      43. Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia 999
      Muhammad Mansoor Alam and Moshe Talpaz

      44. Aromatase Inhibitors for Breast Cancer 1011
      Akm Hossain and Jame Abraham

      45. Evolution of Selective Estrogen and Androgen Receptor Modulators: Status of Current Therapy and New Drug Development 1019
      Gregory T. Wurz and Michael W. DeGregorio

      46. In-Depth Look: anti-TNF-α Therapies 1045
      Satadal Chatterjee and Shobhan Gaddameedhi

      47. Development of Therapeutic Agents: The Maternal—Fetal Perspective 1093
      C. Gedeon, F. Garcia Bournissen and G. Koren

      48. History of Antipsychotic Drug Development 1111
      Shankar S. Gollapudi and Rajan Radhakrishnan

      49. Radiopharmaceuticals and Medical Imaging: Development of Radioimmumoconjugates for Radioimmunoimaging and Radioimmunotherapy of Malignant Diseases 1137
      Gang Niu and Xiaoyuan Chen

      50. Therapeutic Drug Development for Kidney Diseases 1159
      Mitchell H. Rosner, Joshua King, and Peter Monteleone

      51. Targeting Chemokines and Angiogenesis in Arthritis 1185
      Zoltan Szekaneez and Alisa E Koch

      52. Development of Therapeutic Agents: Methods and Approaches in the Development of Vaccines against Protozoan Parasites 1207
      Catherine Ivory and Kris Chadee

      53. Toxicology 1221
      John H. Duffus

      54. The Development of Phosphodiesterase 4 Inhibitors for Allergic and Nonallergic Infl ammatory Diseases of the Airways 1233
      Mark A. Giembycz

      INDEX 1251

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