Description
Book SynopsisDendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agents, drug delivery systems, nucleic acid and RNA delivery vectors and to produce hybrid fibre platforms for nantechnology. Following the work of COST action TD0802, the main objective of which is to improve existing therapies and find new drugs based on dendrimers, the book will provide comprehensive coverage of dendrimer applications. Coverage includes modelling and molecular dynamic studies of dendrimers and dendrons, anionic dendrimer polymers, cationic carbosilane dendrimers and self-assembled multivalent dendrimers. Providing clear indications for future research and applications, this text will appeal to chemists, biologists and materials scientists, working in both academia and industry.
Table of ContentsDendrimers as antiamyloidogenic agents; Dendrimer-amyloid aggregates morphology and cell toxicity; dendrimer-based hybrid fibers as potential platform for 1d-objects in nanotechnology; natural and synthetic biomaterials as composites of advanced drug delivery nano systems (addnss). Biomedical applications; cationic carbosilane dendrimers as non-viral vectors of nucleic acids (oligonucleotide or sirna) for gene therapy purposes; anionic dendritic polymers for biomedical applications; dendrimers as nanovectors for nucleic acid delivery; dendrimeric antigens. New approaches towards detection of ige-mediated drug allergy reactions; molecular dynamics of lysine dendrimers. Computer simulation and nmr; characterization of dendrimers and their interactions with biomolecules for medical use by means of electron magnetic resonance; dendrimers as vectors for small interfering rna transfection in the nervous system; multiscale modeling of dendrimers and dendrons for drug and nucleic acid delivery; poly(aminoester) dendrimers: design, synthesis and characterization; from multivalent dendrons to self-asssembled multivalent dendrimers: a combined experimental and theoretical approach;
