Description
Book SynopsisCombinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context. It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists in chemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the
Trade ReviewThe book is a very useful addition to the area at the undergraduate level, as well as providing a rudimentary introduction for those chemists new to the field. All the basics are covered, ranging from solid supports to linkers to examples of reliable non-peptide solidphase chemistries, as well as the more exotic, with regards to tagging and single bead screening. * Mark Bradley, Chemistry in Britain, March 1999, *
Table of Contents1. Combinatorial synthesis ; 2. Library synthesis on resin beads ; 3. Other solid phases ; 4. Solution phase library synthesis ; 5. Encoded combinatorial synthesis ; 6. Beyond peptide libraries ; 7. Solid phase library chemistry ; 8. Analysis of chemistry and products ; 9. Combinatorial chemistry applications ; Index
