Description
Book SynopsisThis book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings. It includes lifestyle and supplement recommendations for beginning and maintaining autonomic nervous system and mitochondrial health and wellness. The book is organized around a six-pronged mind-body wellness program and contains a series of clinical applications and frequently asked questions. The physiologic need and clinical benefit and synergism of all six aspects working together are detailed, including the underlying biochemistry, with exhaustive references to statistically significant and clinically relevant studies. The book covers a range of clinical disorders, including anxiety, arrhythmia, atherosclerosis, bipolar disease, dementia, depression, fatigue, fibromyalgia, heart diseases, hypertension, mast cell disorder, migraine, and PTSD. Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, primary care, neurology, endocrinology, psychiatry, and integrative and functional medicine. It provides therapy options to the indications and diagnoses published in the authors' book Clinical Autonomic Dysfunction (Springer, 2014).
Table of ContentsTABLE OF CONTENTSDISCLAIMER 6FOREWORD 7PREFACE 8SUMMARY 101. INTRODUCTION 172. ABOUT THE PROGRAM 18Energy Production 21Back To The Program 32The Importance of Antioxidants 333. OMEGA-3 FATTY ACIDS (Prong-1) 47Details of Oxidized LDL and Atherosclerosis Production 51Fish Oil Omega-3s as an Anti-inflammatory 54More Properties of Fish Oil 66Summary of Cumulative Data 704. NITRIC OXIDE (Prong-2) 75The “Universal Messenger” 77Detoxification and the Urea Cycle 89Nitric Oxide Production 92Beet Root Powder 99L-Arginine 100L-Citrulline 105L-Carnitine 109The Anti-Atherosclerotic Molecule 110An Anti-Inflammatory Molecule 113Erectile Dysfunction 115An Antioxidant Molecule 116Heart Failure 117Nitric Oxide in the Nervous System 124The Dark-Side of Nitric Oxide 129Summary 1335. OXIDATIVE STRESS REDUCTION (Prong-3) 138Reduce Mitochondrial Dysfunction 142Oxidative Stress 150Markers of Oxidative Stress 153Aldehydes: Oxidative stress and ROS production vs. Alpha-Lipoic Acid, as Modeled in Diabetes 155Oxidative Stress in Cardiovascular Diseases 159Oxidative Stress I: Biology and Cardiovascular Disease 168Oxidative Stress II: Impact on the Heart and Vasculature 170Oxidative Stress III: Cardiovascular Risk of Obesity, Diabetes, Smoking, and Pollution 175Oxidative Stress and Aging 176Homocysteine 186Folic Acid (Vitamin B9) 191Tryptophan 192Oxidative Stress and Autonomic Neuropathy, Type II Diabetes as a Model 196Application in Bipolar Disease 221Application in Heart Failure 223Application in Fatty Liver Disease 226Application in Mast Cell Activation Syndrome and Food Allergies 228Preventing the Dark-Side of Nitric Oxide 2326. MEDITERRANEAN DIET (Prong-4) 236Disease and the Mediterranean Diet 239Endothelial Function and the Mediterranean Diet 247Polyphenols and the Mediterranean Diet 249The Mediterranean Diet: What To Expect 250Health Benefits of Olive Oil 253The Power of the Grape 256The Incredible Whole Wheat Grain 258Resveratrol 262Antioxidant Effects 263Mediterranean Diet Summary 266Alcohol Consumption 2737. EXERCISE (Prong-5) 276Exercise and the Nervous System 281Antioxidant Effects 286Exercise and Endothelial Function 288Exercise and Physical Activity 2928. PSYCHOSOCIAL STRESS REDUCTION (PRONG-6) 305Hypothalamus-Pituitary-Adrenal Axis Connects Brain and Body 307The Nervous System’s Brain-Body Connections 314Modulation of Parasympathetic and Sympathetic Input to the Heart 318Emotion and Sudden Arrhythmic Death 322Emotions Modulate P&S Activity 327Stress, Emotions, The Vagus Nerve, and Inflammation 330Lateralization of Emotions and P&S Responses 331The Brain-Heart Connection 334Dentistry is Also Connected 337The Vagus Nerve 339The Brain-Gut Connection 344Dynamic Parasympathetic Excess 345Some Comments on Adrenal Fatigue 349Reducing Stress is an Antioxidant 3509. Mind-body wellness program benefits 357Contra-Indications or Interactions 357Alpha-Lipoic Acid Interactions 357Coenzyme Q-10 Interactions 358L-Arginine Interactions 358L-Carnitine Interactions 358L-Citrulline Interactions 359Beet Root Extract (Nitric Oxide Supplement) Interactions 359Lysine Interactions 359Folic Acid Interactions 359Omega-3, Fish Oil Interactions 359Pharmacology and “Functional Medicine” are Complimentary 360Cannabidiol (Marijuana) 361B-Vitamins 362Questionnaires 364Compass 31 Questionnaire 366SF-36 Questionnaire 370Nottingham Health Profile 377Simplified Autonomic Questionnaire 379Questionnaire on Hypermobility Syndromes (EDS and Related Disorders) 380Dysautonomia Drugs Taken In Past Or Present 383Composite Autonomic Scoring Scale (CASS) 384Autonomic Neuropathy Scoring 385Supplements and Nutraceuticals Help to Improve Pharmacology 386Antioxidant Treatment and Atrial Fibrillation 388Anxiety 389Anxiety and Depression 394Neurofeedback 399Atherosclerosis 401Autonomic Dysfunction and Small Fiber Neuropathy and Their Measurements 401Breast Cancer, Oxidative Stress, and Cardiovascular Disease 419Chronic Fatigue Syndrome 420Persistent Fatigue 423Congestive Heart Failure 427Fibromyalgia 428Hypertension 430Hypertension Secondary to Parasympathetic Excess 430Hypertension Secondary to Orthostatic Dysfunction 432Migraine Headaches 433Mitochondrial Dysfunction and Neurodegenerative Disorders 436Post-Traumatic Stress Disorder 449Telomere Length, Longevity, Fish oils, and Antioxidants 455Summation 460Frequently Asked Questions 461The P&S (Autonomic) Nervous Systems 461Dysfunction of the P&S Nervous Systems 465Tests of the P&S Nervous Systems and for Autonomic (P&S) Dysfunction 469Lightheadedness (“Dizziness”) Due to Autonomic Dysfunction 472Diseases that Result from Dysfunction of the P&S (Autonomic) Nervous Systems 482Mitochondria and Mitochondrial Disorders 488REFERENCES 491
