Description
Book SynopsisThis book brings together the most up-to-date knowledge about the role of cholesterol in regulation of ion channels and receptors and the pathological implications of these effects.
Table of ContentsFOREWORD vii
PREFACE ix
CONTRIBUTORS xi
I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES 1
1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES 3
Daniel Wu¨ stner, Lukasz Michael Solanko, and Frederik W. Lund
2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES—AN ENERGETIC PERSPECTIVE 27
Jens A. Lundbæk and Olaf S. Andersen
II CHOLESTEROL REGULATION OF ION CHANNELS 45
3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS 47
Avia Rosenhouse-Dantsker and Irena Levitan
4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS 69
Hwei L. Ong and Indu S. Ambudkar
5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS 91
Elise Balse, Ste´ phane Hatem, and Stanley Nattel
6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS 109
Alex M. Dopico, Anna N. Bukiya, and Aditya K. Singh
7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM 135
Nu´ ria Comes and Antonio Felipe
8 INDIRECT CHANNEL REGULATION BY CHOLESTEROL: THE ROLE OF CAVEOLAE AND CAVEOLINS IN REGULATING KATP CHANNEL FUNCTION 161
Caroline Dart
III CHOLESTEROL REGULATION OF RECEPTORS 181
9 REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR BY CHOLESTEROL AS A BOUNDARY LIPID 183
Francisco J. Barrantes
10 SPECIFIC AND NONSPECIFIC REGULATION OF GPCR FUNCTION BY CHOLESTEROL 205
Gerald Gimpl and Katja Gehrig-Burger
11 STRUCTURAL INSIGHTS INTO CHOLESTEROL INTERACTIONS WITH G-PROTEIN-COUPLED RECEPTORS 231
Jeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov
12 MEMBRANE CHOLESTEROL: IMPLICATIONS IN RECEPTOR FUNCTION 255
Sandeep Shrivastava and Amitabha Chattopadhyay
13 THE ROLE OF CHOLESTEROL AND LIPID RAFTS IN REGULATION OF TLR RECEPTORS 273
Ruxana T. Sadikot
INDEX 281
