Description
Book SynopsisThe use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the foundation of emerging disciplines of proteomics, chemical biology, structure biology, and chemical proteomics.
Chemical Reagents for Protein Modification, Fourth Edition provides a comprehensive review of reagents used for the chemical modification of proteins, representing a major revision of the work presented in previous editions. The completely updated Fourth Edition is substantially larger and includes five new chapters:
- Alkylating Agents
- Acylating Agents
- Nitration and Nitrosylation
- Oxidation
- Modification of Proteins with Reducing Agents
There is grea
Table of Contents
Introduction to the Chemical Modification of Proteins. Alkylating Agents. Acylating Agents. Nitration and Nitrosylation. Oxidation. Modification of Proteins with Reducing Agents. Chemical Modification of Cysteine. Modification of Sulfhydryl Groups in Proteins for Analysis. Conjugate Nucleophilic Addition (Michael Addition). Alkyl Alkanethiosulfonates. Chemical Modification of Cystine. Cleavage of Disulfide Bonds. Modification of Methionine. Modification of Carboxyl Groups in Proteins. Modification of Tyrosine Residues. Modification of Tryptophan. Modification of Amino Groups. Modification of Histidine. Modification of Arginine. Index.
