Description
Book SynopsisSynthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.
Table of ContentsSynthetic Tools for the Elucidation of Biological Mechanisms; The Application of Diversity-oriented Synthesis in Chemical Biology; Biology-oriented Synthesis; Lead- and Fragment-oriented Synthesis; Principles and Applications of Fragment-based Drug Discovery for Chemical Probes; Function-driven Discovery of Bioactive Small Molecules; DNA-encoded Library Technology (ELT); Engineering Chemistry to Enable Bioactive Small Molecule Discovery; Genetically Encoded Cyclic Peptide Libraries; Modern Methods for the Synthesis of Carbohydrates; Precursor-directed Biosynthesis and Semi-synthesis of Natural Products; Site-specific Protein Modification and Bio-orthogonal Chemistry; Chemical Protein Synthesis: Strategies and Biological Applications; Subject Index
