Description
Book SynopsisCell-Penetrating Peptides The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs.
In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell.
Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture.
- Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles
- Presents the chemical and biological characteristics of CPP action in vitro and in vivo
- Describes the structure and design principles of both synthetic and naturally occurring CPPs
- Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials
Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.
Table of ContentsIntroduction
PART 1: DESGIN OF CPPS
Classification
Tat
Penetration
Guanidino transporter
Arg-rich peptides
Transportan
Hydrophobic peptides
Foldamers
PART 2: MECHANISM OF CPPS
Peptide structure
Cellular uptake
Endosomal escape
Pharmacokinetics
PART 3: DELIVERY TOOLS
Drug delivery
Peptide & protein delivery
Nucleic acid delivery
Polymeric micelles
Lipid-based nanoparticles
PART 4: APPLICATIONS
Oral delivery
Intranasal delivery
Clinical trials
CPPs in Plants
